tert-butyl 4-(1-butyl-1H-tetrazol-5-yl)-4-[{4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]benzyl}(2-propyn-1-yl)amino]-1-piperidinecarboxylate

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Chemical Name:tert-butyl 4-(1-butyl-1H-tetrazol-5-yl)-4-[{4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]benzyl}(2-propyn-1-yl)amino]-1-piperidinecarboxylate
CAS No.:1620482-88-3
Molecular Formula:C₂₉H₄₂N₈O₃
Molecular Weight:550.704
Hs Code.:

Synonyms:tert-butyl 4-(1-butyl-1H-tetrazol-5-yl)-4-[{4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]benzyl}(2-propyn-1-yl)amino]-1-piperidinecarboxylate

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Chemical Property of tert-butyl 4-(1-butyl-1H-tetrazol-5-yl)-4-[{4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]benzyl}(2-propyn-1-yl)amino]-1-piperidinecarboxylate

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Technology Process of tert-butyl 4-(1-butyl-1H-tetrazol-5-yl)-4-[{4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]benzyl}(2-propyn-1-yl)amino]-1-piperidinecarboxylate

There total 2 articles about tert-butyl 4-(1-butyl-1H-tetrazol-5-yl)-4-[{4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]benzyl}(2-propyn-1-yl)amino]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 2769-64-4
n-butyl isonitrile

: 1620483-13-7
N-{4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]benzyl}-2-propyn-1-amine

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1620482-88-3
tert-butyl 4-(1-butyl-1H-tetrazol-5-yl)-4-[{4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]benzyl}(2-propyn-1-yl)amino]-1-piperidinecarboxylate

Guidance literature:: With trimethylsilylazide; In methanol; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ja505517t

Reference yield:

: 1620483-11-5
{4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methanol

: 1620482-88-3
tert-butyl 4-(1-butyl-1H-tetrazol-5-yl)-4-[{4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]benzyl}(2-propyn-1-yl)amino]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfur trioxide pyridine complex; triethylamine / ethyl acetate; dimethyl sulfoxide / 0.33 h / 0 - 20 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / acetonitrile; dichloromethane / 15 h / 0 - 20 °C / Inert atmosphere

3: trimethylsilylazide / methanol / 0 - 20 °C / Inert atmosphere

With trimethylsilylazide; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetonitrile;
DOI:10.1021/ja505517t