(-)-p-fluorophenyl (2E)-4-<((2'R)-2'-(bromomethyl)butanoyl)oxy>-2-butenoate

Base Information

Chemical Name:(-)-p-fluorophenyl (2E)-4-<((2'R)-2'-(bromomethyl)butanoyl)oxy>-2-butenoate
CAS No.:163457-29-2
Molecular Formula:C₁₅H₁₆BrFO₄
Molecular Weight:359.192
Hs Code.:

Synonyms:(-)-p-fluorophenyl (2E)-4-<((2'R)-2'-(bromomethyl)butanoyl)oxy>-2-butenoate

Suppliers and Price of (-)-p-fluorophenyl (2E)-4-<((2'R)-2'-(bromomethyl)butanoyl)oxy>-2-butenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-p-fluorophenyl (2E)-4-<((2'R)-2'-(bromomethyl)butanoyl)oxy>-2-butenoate

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Technology Process of (-)-p-fluorophenyl (2E)-4-<((2'R)-2'-(bromomethyl)butanoyl)oxy>-2-butenoate

There total 10 articles about (-)-p-fluorophenyl (2E)-4-<((2'R)-2'-(bromomethyl)butanoyl)oxy>-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 163457-38-3
(E)-4-((R)-2-Hydroxymethyl-butyryloxy)-but-2-enoic acid 4-fluoro-phenyl ester

: 163457-29-2
(-)-p-fluorophenyl (2E)-4-<((2'R)-2'-(bromomethyl)butanoyl)oxy>-2-butenoate

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; for 3.5h; Ambient temperature;
DOI:10.1021/jo951653e

Reference yield:

: 163457-34-9
(+)-(4S)-3-<(2'R)-2'-((benzyloxy)methyl)butanoyl>-4-benzyl-2-oxazolidinone

: 163457-29-2
(-)-p-fluorophenyl (2E)-4-<((2'R)-2'-(bromomethyl)butanoyl)oxy>-2-butenoate

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / H₂ / Pd on carbon / ethanol / 72 h / Ambient temperature

2: 100 percent / 4-(N,N-dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 5 h / Ambient temperature

3: aq. H₂O₂, LiOH*H₂O / tetrahydrofuran / 2 h / Ambient temperature

4: 100 percent / 4-(N,N-dimethylamino)pyridine, DCC / 1,2-dichloro-ethane / 12 h / Ambient temperature

5: 97 percent / AcOH, H₂O / tetrahydrofuran / 12 h / 40 °C

6: 85 percent / CBr₄, PPh₃ / CH₂Cl₂ / 3.5 h / Ambient temperature

With dmap; lithium hydroxide; carbon tetrabromide; water; hydrogen; dihydrogen peroxide; acetic acid; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo951653e

Reference yield:

: 371-41-5
4-Fluorophenol

: 163457-29-2
(-)-p-fluorophenyl (2E)-4-<((2'R)-2'-(bromomethyl)butanoyl)oxy>-2-butenoate

Guidance literature:: Multi-step reaction with 5 steps

1: 4-(N,N-dimethylamino)pyridine, DCC / 1,2-dichloro-ethane / 14 h / Ambient temperature

2: 90 percent / aq. AcOH / tetrahydrofuran / 10 h / Ambient temperature

3: 100 percent / 4-(N,N-dimethylamino)pyridine, DCC / 1,2-dichloro-ethane / 12 h / Ambient temperature

4: 97 percent / AcOH, H₂O / tetrahydrofuran / 12 h / 40 °C

5: 85 percent / CBr₄, PPh₃ / CH₂Cl₂ / 3.5 h / Ambient temperature

With dmap; carbon tetrabromide; water; acetic acid; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo951653e