Benzoic acid (2R,4S,5S)-4-acetoxy-5-(6-amino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:Benzoic acid (2R,4S,5S)-4-acetoxy-5-(6-amino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester
CAS No.:201287-86-7
Molecular Formula:C₁₉H₁₉N₅O₅
Molecular Weight:397.39
Hs Code.:

Synonyms:Benzoic acid (2R,4S,5S)-4-acetoxy-5-(6-amino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

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Chemical Property of Benzoic acid (2R,4S,5S)-4-acetoxy-5-(6-amino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

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Technology Process of Benzoic acid (2R,4S,5S)-4-acetoxy-5-(6-amino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

There total 1 articles about Benzoic acid (2R,4S,5S)-4-acetoxy-5-(6-amino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 170079-20-6
1,2-di-O-acetyl-5-O-benzoyl-3-deoxy-L-erythro-pentofuranose

: 201287-86-7
Benzoic acid (2R,4S,5S)-4-acetoxy-5-(6-amino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With tin(IV) chloride; In acetonitrile; Ambient temperature;
DOI:10.1016/0960-894X(96)00293-4 DOI:10.1080/07328319708006190 DOI:10.1080/07328319808004708

Reference yield: 40.0%

: 201287-86-7
Benzoic acid (2R,4S,5S)-4-acetoxy-5-(6-amino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

: 201287-87-8
Benzoic acid (2R,4S,5S)-5-(6-amino-purin-9-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With sodium methylate; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/0960-894X(96)00293-4

Reference yield:

: 201287-86-7
Benzoic acid (2R,4S,5S)-4-acetoxy-5-(6-amino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

: 201287-89-0
Benzoic acid (2R,5S)-5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / CH₃ONa / tetrahydrofuran

2: 55 percent / pyridine

3: 60 percent / TBAF / tetrahydrofuran / Ambient temperature

With pyridine; tetrabutyl ammonium fluoride; sodium methylate; In tetrahydrofuran;
DOI:10.1080/07328319708006190