bromo-acetic acid 3-benzyl-5-chloro-8-methyl-2,4-dioxo-1,2,3,4-tetrahydro-quinolin-3-yl ester

Base Information

Chemical Name:bromo-acetic acid 3-benzyl-5-chloro-8-methyl-2,4-dioxo-1,2,3,4-tetrahydro-quinolin-3-yl ester
CAS No.:220462-63-5
Molecular Formula:C₁₉H₁₅BrClNO₄
Molecular Weight:436.689
Hs Code.:

Synonyms:bromo-acetic acid 3-benzyl-5-chloro-8-methyl-2,4-dioxo-1,2,3,4-tetrahydro-quinolin-3-yl ester

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Chemical Property of bromo-acetic acid 3-benzyl-5-chloro-8-methyl-2,4-dioxo-1,2,3,4-tetrahydro-quinolin-3-yl ester

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Technology Process of bromo-acetic acid 3-benzyl-5-chloro-8-methyl-2,4-dioxo-1,2,3,4-tetrahydro-quinolin-3-yl ester

There total 4 articles about bromo-acetic acid 3-benzyl-5-chloro-8-methyl-2,4-dioxo-1,2,3,4-tetrahydro-quinolin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 598-21-0
2-Bromoacetyl bromide

: 220462-69-1
3-benzyl-5-chloro-3-hydroxy-8-methyl-1,2,3,4-tetrahydroquinoline-2,4-dione

: 220462-63-5
bromo-acetic acid 3-benzyl-5-chloro-8-methyl-2,4-dioxo-1,2,3,4-tetrahydro-quinolin-3-yl ester

Guidance literature:: With pyridine; In benzene; r.t., 2 h then 60 deg C, 1 h;
DOI:10.3987/COM-98-8305

Reference yield:

: 607-81-8
diethyl 2-benzylmalonate

: 220462-63-5
bromo-acetic acid 3-benzyl-5-chloro-8-methyl-2,4-dioxo-1,2,3,4-tetrahydro-quinolin-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 43 percent / 200-210 deg C, 1 h then 280 deg C, 1.5 h then 295-300 deg C, 45 min

2: 89 percent / NaOH, peroxyacetic acid / acetic acid / 0.5 h / Ambient temperature

3: 81 percent / pyridine / benzene / r.t., 2 h then 60 deg C, 1 h

With pyridine; peracetic acid; sodium hydroxide; In acetic acid; benzene;
DOI:10.3987/COM-98-8305

Reference yield:

: 220462-68-0
3-benzyl-5-chloro-4-hydroxy-8-methyl-1H-quinolin-2-one

: 220462-63-5
bromo-acetic acid 3-benzyl-5-chloro-8-methyl-2,4-dioxo-1,2,3,4-tetrahydro-quinolin-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / NaOH, peroxyacetic acid / acetic acid / 0.5 h / Ambient temperature

2: 81 percent / pyridine / benzene / r.t., 2 h then 60 deg C, 1 h

With pyridine; peracetic acid; sodium hydroxide; In acetic acid; benzene;
DOI:10.3987/COM-98-8305