(R)-1-(1-(3-cyanophenyl)ethyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Base Information

Chemical Name:(R)-1-(1-(3-cyanophenyl)ethyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile
CAS No.:1539314-42-5
Molecular Formula:C₁₉H₁₂F₃N₃
Molecular Weight:339.32
Hs Code.:

Synonyms:(R)-1-(1-(3-cyanophenyl)ethyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

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Chemical Property of (R)-1-(1-(3-cyanophenyl)ethyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Chemical Property:

Purity/Quality:

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Technology Process of (R)-1-(1-(3-cyanophenyl)ethyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

There total 8 articles about (R)-1-(1-(3-cyanophenyl)ethyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1539314-79-8
4-fluoro-2-(trifluoromethyl)-3-((trimethylsilyl)ethynyl)benzonitrile

: 127852-31-7
(R)-α-(m-cyanophenyl)ethylamine

: 1539314-42-5
(R)-1-(1-(3-cyanophenyl)ethyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Guidance literature:: With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 60 ℃; for 17h; Sealed tube; Inert atmosphere;

Reference yield:

: 1607434-31-0
C₈H₄F₄INO

: 1539314-42-5
(R)-1-(1-(3-cyanophenyl)ethyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis(trichloromethyl) carbonate; triethylamine / chloroform / 1.25 h / Cooling with ice

2.1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / toluene / 0.17 h / Sealed tube; Sonication

2.2: 60 °C / Sonication

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 17 h / 60 °C / Sealed tube; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; bis(trichloromethyl) carbonate; potassium carbonate; triethylamine; diisopropylamine; In 1-methyl-pyrrolidin-2-one; chloroform; toluene;

Reference yield:

: 194853-86-6
4-fluoro-2-(trifluoromethyl)benzonitrile

: 1539314-42-5
(R)-1-(1-(3-cyanophenyl)ethyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -45 °C

1.2: 1 h / -70 - -52 °C

2.1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / toluene / 0.17 h / Sealed tube; Sonication

2.2: 60 °C / Sonication

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 17 h / 60 °C / Sealed tube; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; toluene;