(S)-2-{(S)-2-[4-(benzyloxy)phenyl]-2-[(3R,4R)-3,4-bis(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl]ethyl}-4-isopropyl-4,5-dihydrooxazole

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Chemical Name:(S)-2-{(S)-2-[4-(benzyloxy)phenyl]-2-[(3R,4R)-3,4-bis(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl]ethyl}-4-isopropyl-4,5-dihydrooxazole
CAS No.:1206770-04-8
Molecular Formula:C₄₄H₇₁NO₅Si₂
Molecular Weight:750.222
Hs Code.:

Synonyms:(S)-2-{(S)-2-[4-(benzyloxy)phenyl]-2-[(3R,4R)-3,4-bis(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl]ethyl}-4-isopropyl-4,5-dihydrooxazole

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Chemical Property of (S)-2-{(S)-2-[4-(benzyloxy)phenyl]-2-[(3R,4R)-3,4-bis(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl]ethyl}-4-isopropyl-4,5-dihydrooxazole

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Technology Process of (S)-2-{(S)-2-[4-(benzyloxy)phenyl]-2-[(3R,4R)-3,4-bis(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl]ethyl}-4-isopropyl-4,5-dihydrooxazole

There total 1 articles about (S)-2-{(S)-2-[4-(benzyloxy)phenyl]-2-[(3R,4R)-3,4-bis(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl]ethyl}-4-isopropyl-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 6793-92-6
p-benzyloxyphenylbromide

: 1206770-03-7
(S)-2-{(E)-2-[(3R,4R)-3,4-bis(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl]vinyl}-4-isopropyl-4,5-dihydrooxazole

: 1206770-04-8
(S)-2-{(S)-2-[4-(benzyloxy)phenyl]-2-[(3R,4R)-3,4-bis(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl]ethyl}-4-isopropyl-4,5-dihydrooxazole

Guidance literature:: p-benzyloxyphenylbromide; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃;

(S)-2-{(E)-2-[(3R,4R)-3,4-bis(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl]vinyl}-4-isopropyl-4,5-dihydrooxazole; In tetrahydrofuran; pentane; at -48 ℃; for 0.666667h;
DOI:10.1039/b918091e

Reference yield:

: 1206770-04-8
(S)-2-{(S)-2-[4-(benzyloxy)phenyl]-2-[(3R,4R)-3,4-bis(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl]ethyl}-4-isopropyl-4,5-dihydrooxazole

: 1206770-05-9
(S)-3-[4-(benzyloxy)phenyl]-3-[(3R,4R)-3,4-bis(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl]propanoic acid

Guidance literature:: (S)-2-{(S)-2-[4-(benzyloxy)phenyl]-2-[(3R,4R)-3,4-bis(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl]ethyl}-4-isopropyl-4,5-dihydrooxazole; With methyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 0.0833333h;

With water; lithium hydroxide; In tetrahydrofuran; at 20 - 45 ℃; for 6h; Heating;

With potassium hydroxide; In methanol; tert-butyl alcohol; for 30h; Reflux;
DOI:10.1039/b918091e