ethyl 2-<5-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-1H-tetrazol-1-yl>acetate

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Chemical Name:ethyl 2-<5-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-1H-tetrazol-1-yl>acetate
CAS No.:141463-29-8
Molecular Formula:C₂₀H₃₅N₅O₅S
Molecular Weight:457.594
Hs Code.:

Synonyms:ethyl 2-<5-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-1H-tetrazol-1-yl>acetate

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Chemical Property of ethyl 2-<5-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-1H-tetrazol-1-yl>acetate

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Technology Process of ethyl 2-<5-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-1H-tetrazol-1-yl>acetate

There total 1 articles about ethyl 2-<5-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-1H-tetrazol-1-yl>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 56610-83-4
1-ethoxycarbonylmethyl-1H-tetrazole-5-thiol

: 107202-61-9
(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

: 141463-29-8
ethyl 2-<5-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-1H-tetrazol-1-yl>acetate

Guidance literature:: With 4-methyl-morpholine; In ethanol; at 85 ℃; for 2h;
DOI:10.1021/jm00089a023

Reference yield:

: 141463-29-8
ethyl 2-<5-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-1H-tetrazol-1-yl>acetate

: 2-[5-({(2R,3S)-3-[(Boc-L-phenylalanyl-L-histidyl)amino]-4-cyclohexyl-2-hydroxy-1-butyl}thio)-1H-tetrazol-1-yl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) HCl gas, 2.) triethylamine / 1.) MeOH, RT, 1 h, 2.) CH₂Cl₂

2: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, triethylamine / CH₂Cl₂ / 3.5 h / Ambient temperature

3: 28 percent / K₂CO₃ / ethanol / 18 h / Ambient temperature

With hydrogenchloride; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm00089a023

Reference yield:

: 141463-29-8
ethyl 2-<5-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-1H-tetrazol-1-yl>acetate

: 2-[5-({(2R,3S)-3-[(Boc-L-phenylalanyl-L-histidyl)amino]-4-cyclohexyl-2-hydroxy-1-butyl}thio)-1H-tetrazol-1-yl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) HCl gas, 2.) triethylamine / 1.) MeOH, RT, 1 h, 2.) CH₂Cl₂

2: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, triethylamine / CH₂Cl₂ / 3.5 h / Ambient temperature

3: 40 percent / NH₃ gas / ethanol / 5 h / Ambient temperature

With hydrogenchloride; ammonia; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm00089a023