2H-Pyrazol-3-ylamine

Base Information

• Chemical Name: 2H-Pyrazol-3-ylamine
• CAS No.: 916420-28-5
• Molecular Formula: C₃H₅N₃
• Molecular Weight: 83.0928
• Mol file: 916420-28-5.mol

Synonyms:Pyrazole, 3(or 5)-amino- (6CI,7CI); Pyrazole,3-amino- (8CI); (5-1H-Pyrazolyl)amine; 1H-Pyrazol-3-ylamine;1H-Pyrazol-5-amine; 1H-Pyrazole-3-amine; 3(5)-Aminopyrazole;3-AP; 3-Amino-1H-pyrazole; 3-Amino-2H-pyrazole; 3-Aminopyrazole;5-Aminopyrazole; 5-Pyrazolamine; NSC 76122

Chemical Property of 2H-Pyrazol-3-ylamine

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 288.454°C at 760 mmHg
• Flash Point: 182.569°C
• PSA: 54.70000
• Density: 1.313g/cm³
• LogP: 0.57310
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

5-Amino-1H-pyrazole 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C:Corrosive;;
• Statements: R22:; R34:; R36/37/38:
• Safety Statements: S26:; S36/37/39:; S45:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Pyrazol-3-ylamine

There total 7 articles about 2H-Pyrazol-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-nitro-1H-pyrazole (26621-44-3) → 3-aminopyrazole (1820-80-0,916420-28-5)

Guidance literature:

With cyclohexa-1,4-diene; 5%-palladium/activated carbon; In methanol; at 120 ℃; for 0.0833333h; Microwave irradiation;

DOI:10.1016/j.tetlet.2009.12.005

Reference yield: 60.0%

trans-β-chloroacrylonitrile (871-29-4,3721-37-7,3721-38-8) → 3-aminopyrazole (1820-80-0,916420-28-5)

Guidance literature:

With hydrazine hydrate; In methanol; for 4h; Heating;

Reference yield: 38.0%

→ thiodiazoimidazole + 3-aminopyrazole (1820-80-0,916420-28-5)

Guidance literature:

upstream raw materials:

3-aminopyrazole-4-carboxylic acid

trans-β-chloroacrylonitrile

3-nitro-1H-pyrazole

cyanoacetaldehyde

Refernces

• 1、 -. "ADENOSINE A3 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF". . . Retrieved 2012/03/12.
• 2、 -. "Heterocyclic dihydropyrimidine compounds". . . Retrieved 2008/06/13.