octahydro-3,6-dimethyl-9-[3-(p-chlorophenyl)propyl]-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one

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Chemical Name:octahydro-3,6-dimethyl-9-[3-(p-chlorophenyl)propyl]-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
CAS No.:181884-83-3
Molecular Formula:C₂₃H₂₉ClO₅
Molecular Weight:420.933
Hs Code.:

Synonyms:octahydro-3,6-dimethyl-9-[3-(p-chlorophenyl)propyl]-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one

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Chemical Property of octahydro-3,6-dimethyl-9-[3-(p-chlorophenyl)propyl]-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one

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Technology Process of octahydro-3,6-dimethyl-9-[3-(p-chlorophenyl)propyl]-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one

There total 3 articles about octahydro-3,6-dimethyl-9-[3-(p-chlorophenyl)propyl]-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 467223-70-7
(1''S,1'''R,3''S,6''R)-(2''E)-2-[2'-[3''-(1'''-carboxy-4'''-p-chlorophenylbutyl)-6''-methyl-2''-[(trimethylsilyl)methylene]cyclohexyl]ethyl]-2,5,5-trimethyl-1,3-dioxane

: 181884-83-3
octahydro-3,6-dimethyl-9-[3-(p-chlorophenyl)propyl]-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one

Guidance literature:: (1''S,1'''R,3''S,6''R)-(2''E)-2-[2'-[3''-(1'''-carboxy-4'''-p-chlorophenylbutyl)-6''-methyl-2''-[(trimethylsilyl)methylene]cyclohexyl]ethyl]-2,5,5-trimethyl-1,3-dioxane; With ozone; In dichloromethane; at -78 ℃; under 362.004 Torr;

With sulfuric acid; silica gel; In dichloromethane; at 20 ℃;
DOI:10.1021/jm020142z

Reference yield:

: 64473-35-4
3-(4-chlorophenyl)propyl bromide

: 181884-83-3
octahydro-3,6-dimethyl-9-[3-(p-chlorophenyl)propyl]-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, hexane, a) from -78 deg C to RT, b) 50 deg C, 2 h, 2.) THF, hexane, RT, 5 h

2: 1.) O₃, 2.) aq. H₂SO₄, silica gel / 1.) CH₂Cl₂, -78 deg C, 4 psi, 5 min, 2.) CH₂Cl₂, RT, 4 d

With sulfuric acid; silica gel; ozone; lithium diisopropyl amide;
DOI:10.1021/jm9603577

Reference yield:

: 116399-92-9
2,5,5-trimethyl-2-<2'-<4''-(carboxymethyl)-1''(R)-methyl-3''-<(trimethylsilyl)methylene>cyclohex-2''-yl>ethyl>-1,3-dioxane

: 181884-83-3
octahydro-3,6-dimethyl-9-[3-(p-chlorophenyl)propyl]-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, hexane, a) from -78 deg C to RT, b) 50 deg C, 2 h, 2.) THF, hexane, RT, 5 h

2: 1.) O₃, 2.) aq. H₂SO₄, silica gel / 1.) CH₂Cl₂, -78 deg C, 4 psi, 5 min, 2.) CH₂Cl₂, RT, 4 d

With sulfuric acid; silica gel; ozone; lithium diisopropyl amide;
DOI:10.1021/jm9603577