4-(3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)-3-ethynylbenzoicacid

Base Information

Chemical Name:4-(3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)-3-ethynylbenzoicacid
CAS No.:1562520-69-7
Molecular Formula:C₃₇H₃₅N₃O₄
Molecular Weight:585.703
Hs Code.:

Synonyms:4-(3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)-3-ethynylbenzoicacid

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Chemical Property of 4-(3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)-3-ethynylbenzoicacid

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Technology Process of 4-(3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)-3-ethynylbenzoicacid

There total 4 articles about 4-(3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)-3-ethynylbenzoicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(9-(2-(chlorocarbonyl)phenyl)-6-(diethylamino)-3H-xanthen-3-ylidene)-N-ethylethanaminium chloride

: 1260796-10-8
4-amino-3-ethynylbenzoic acid

: 1562520-69-7
4-(3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)-3-ethynylbenzoicacid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 5h;
DOI:10.1021/ol5001389

Reference yield:

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 1562520-69-7
4-(3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)-3-ethynylbenzoicacid

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine iodine monochloride / methanol / 2 h / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

3: potassium carbonate / methanol / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyridine iodine monochloride; potassium carbonate; diisopropylamine; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol5001389

Reference yield:

: 2122-63-6
4-amino-3-iodobenzoic acid

: 1562520-69-7
4-(3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)-3-ethynylbenzoicacid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

2: potassium carbonate / methanol / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; diisopropylamine; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol5001389