((4S,4aR,8aR)-6-Methylene-1-oxo-octahydro-isochromen-4-yl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:((4S,4aR,8aR)-6-Methylene-1-oxo-octahydro-isochromen-4-yl)-carbamic acid tert-butyl ester
CAS No.:173027-97-9
Molecular Formula:C₁₅H₂₃NO₄
Molecular Weight:281.352
Hs Code.:

Synonyms:((4S,4aR,8aR)-6-Methylene-1-oxo-octahydro-isochromen-4-yl)-carbamic acid tert-butyl ester

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Chemical Property of ((4S,4aR,8aR)-6-Methylene-1-oxo-octahydro-isochromen-4-yl)-carbamic acid tert-butyl ester

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Technology Process of ((4S,4aR,8aR)-6-Methylene-1-oxo-octahydro-isochromen-4-yl)-carbamic acid tert-butyl ester

There total 1 articles about ((4S,4aR,8aR)-6-Methylene-1-oxo-octahydro-isochromen-4-yl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 173027-96-8
(5S,1'R,6'R)-tert-butyl 5-[6-(methoxycarbonyl)-3-methylenecyclohexyl]-2,2-dimethyl-3,1-oxazolidinecarboxylate

: 173027-97-9
((4S,4aR,8aR)-6-Methylene-1-oxo-octahydro-isochromen-4-yl)-carbamic acid tert-butyl ester

: (1R,2R)-2-((S)-1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-4-methylene-cyclohexanecarboxylic acid methyl ester

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol; at 60 ℃; for 0.5h;
DOI:10.1016/S0040-4020(98)00219-1

Reference yield:

: 173027-97-9
((4S,4aR,8aR)-6-Methylene-1-oxo-octahydro-isochromen-4-yl)-carbamic acid tert-butyl ester

: (1R,2R)-2-((S)-1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-4-methylene-cyclohexanecarboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 18h;
DOI:10.1016/S0040-4020(98)00219-1

Reference yield:

: 173027-97-9
((4S,4aR,8aR)-6-Methylene-1-oxo-octahydro-isochromen-4-yl)-carbamic acid tert-butyl ester

: (2S,1'R,2'R)-2-(2-carboxy-5-methylenecyclohexyl)glycine

Guidance literature:: Multi-step reaction with 3 steps

1: NaOH / tetrahydrofuran; H₂O / 18 h / 0 - 20 °C

2: molecular sieves 4A; pyridinium dichromate / dimethylformamide / 20 °C

3: 58 mg / trifluoroacetic acid / CH₂Cl₂ / 1 h / 0 - 20 °C

With sodium hydroxide; dipyridinium dichromate; 4 A molecular sieve; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1: Hydrolysis / 2: Oxidation / 3: deprotection;
DOI:10.1016/S0040-4020(98)00219-1