3-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 3-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 859155-89-8
• Molecular Formula: C11H19NO5
• Molecular Weight: 245.276
• Hs Code.: 2934999090
• Mol file: 859155-89-8.mol

Synonyms:2-[4-[(2-methylpropan-2-yl)oxycarbonyl]morpholin-3-yl]acetic acid

Chemical Property of 3-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.482
• Boiling Point: 388.244 °C at 760 mmHg
• Flash Point: 188.603 °C
• PSA: 76.07000
• Density: 1.18 g/cm³
• LogP: 1.03490
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

3-Carboxymethyl-morpholine-4-carboxylic acid tert-butyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-N-Boc-Morpholine-3-Acetic Acid is a useful research chemical.

Technology Process of 3-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 4 articles about 3-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-Butyl 3-(2-ethoxy-2-oxoethyl)morpholine-4-carboxylate (761460-02-0) → 2-(4-(tert-butoxycarbonyl)morpholin-3-yl)acetic acid (859155-89-8,761460-03-1,839710-38-2)

Guidance literature:

tert-Butyl 3-(2-ethoxy-2-oxoethyl)morpholine-4-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; ethanol; at 80 ℃; for 4h;

With hydrogenchloride; In water;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 2-(4-(tert-butoxycarbonyl)morpholin-3-yl)acetic acid (859155-89-8,761460-03-1,839710-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: water; lithium hydroxide / ethanol; tetrahydrofuran / 4 h / 80 °C

With water; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

ethyl 2-(morpholin-3-yl)acetate (81684-84-6) → 2-(4-(tert-butoxycarbonyl)morpholin-3-yl)acetic acid (859155-89-8,761460-03-1,839710-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: water; lithium hydroxide / ethanol; tetrahydrofuran / 4 h / 80 °C

With water; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

upstream raw materials:

di-tert-butyl dicarbonate

tert-Butyl 3-(2-ethoxy-2-oxoethyl)morpholine-4-carboxylate

ethyl 2-(morpholin-3-yl)acetate

Downstream raw materials:

tert-butyl 3-[2-(4-benzyl-1,4-diazepan-1-yl)-2-oxoethyl]morpholine-4-carboxylate

tert-butyl 3-(2-hydroxyethyl)morpholine-4-carboxylate

methyl 3-(3-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)-5-(trifluoromethyl)benzoate

methyl 3-(3-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)-5-(trifluoromethyl)benzoate

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