diethyl 2-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-ylmethyl)benzoyl]-L-glutamate

Base Information

Chemical Name:diethyl 2-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-ylmethyl)benzoyl]-L-glutamate
CAS No.:848081-17-4
Molecular Formula:C₂₃H₂₆N₄O₆S
Molecular Weight:486.549
Hs Code.:

Synonyms:diethyl 2-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-ylmethyl)benzoyl]-L-glutamate

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Chemical Property of diethyl 2-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-ylmethyl)benzoyl]-L-glutamate

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Technology Process of diethyl 2-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-ylmethyl)benzoyl]-L-glutamate

There total 5 articles about diethyl 2-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-ylmethyl)benzoyl]-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.4%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 848081-16-3
4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-ylmethyl)benzoic acid

: 848081-17-4
diethyl 2-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-ylmethyl)benzoyl]-L-glutamate

Guidance literature:: With triethylamine; isobutyl chloroformate; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1002/jhet.5570410613

Reference yield:

: 51934-41-9
4-iodobenzoic acid ethyl ester

: 848081-17-4
diethyl 2-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-ylmethyl)benzoyl]-L-glutamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 84 percent / palladium diacetate; aq. tetrabutylammonium chloride; sodium bicarbonate / 30 h / 80 °C

2.1: 33 percent / triethylamine; sulfur powd. / dimethylformamide / 2 h / 20 °C

3.1: 51 percent / dimethylsulfone / 0.5 h / 120 - 130 °C

4.1: aq. NaOH / ethanol / 18 h / 20 °C

4.2: 87 percent / aq. HCl / 2 h / 0 °C / pH 4

5.1: 51.4 percent / triethyl amine; isobutyl chloroformate / dimethylformamide / 0 - 20 °C

With sodium hydroxide; dimethylsulfone; tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate; sulfur; triethylamine; isobutyl chloroformate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570410613

Reference yield:

: 151864-81-2
ethyl 4-(3-oxopropyl)benzoate

: 848081-17-4
diethyl 2-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-ylmethyl)benzoyl]-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 33 percent / triethylamine; sulfur powd. / dimethylformamide / 2 h / 20 °C

2.1: 51 percent / dimethylsulfone / 0.5 h / 120 - 130 °C

3.1: aq. NaOH / ethanol / 18 h / 20 °C

3.2: 87 percent / aq. HCl / 2 h / 0 °C / pH 4

4.1: 51.4 percent / triethyl amine; isobutyl chloroformate / dimethylformamide / 0 - 20 °C

With sodium hydroxide; dimethylsulfone; sulfur; triethylamine; isobutyl chloroformate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570410613