(S)-5-Cyclohexyl-2,2-difluoro-4-{(S)-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-3-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-yl]-propionylamino}-3-oxo-pentanoic acid ethyl ester

Base Information

Chemical Name:(S)-5-Cyclohexyl-2,2-difluoro-4-{(S)-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-3-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-yl]-propionylamino}-3-oxo-pentanoic acid ethyl ester
CAS No.:135727-11-6
Molecular Formula:C₃₅H₄₅Cl₃F₂N₆O₁₀S₂
Molecular Weight:918.264
Hs Code.:

(S)-5-Cyclohexyl-2,2-difluoro-4-{(S)-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-3-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-yl]-propionylamino}-3-oxo-pentanoic acid ethyl ester

Synonyms:(S)-5-Cyclohexyl-2,2-difluoro-4-{(S)-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-3-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-yl]-propionylamino}-3-oxo-pentanoic acid ethyl ester

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Chemical Property of (S)-5-Cyclohexyl-2,2-difluoro-4-{(S)-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-3-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-yl]-propionylamino}-3-oxo-pentanoic acid ethyl ester

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Technology Process of (S)-5-Cyclohexyl-2,2-difluoro-4-{(S)-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-3-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-yl]-propionylamino}-3-oxo-pentanoic acid ethyl ester

There total 8 articles about (S)-5-Cyclohexyl-2,2-difluoro-4-{(S)-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-3-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-yl]-propionylamino}-3-oxo-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 135704-19-7,142185-83-9
(3R,4S)-5-Cyclohexyl-2,2-difluoro-3-hydroxy-4-{(S)-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-3-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-yl]-propionylamino}-pentanoic acid ethyl ester

: 135727-11-6
(S)-5-Cyclohexyl-2,2-difluoro-4-{(S)-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-3-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-yl]-propionylamino}-3-oxo-pentanoic acid ethyl ester

Guidance literature:: With dichloro-acetic acid; dicyclohexyl-carbodiimide; In dichloromethane; dimethyl sulfoxide; for 18h; Ambient temperature;
DOI:10.1021/jm00092a006

Reference yield:

: 135704-30-2
(S)-3-(2-Amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-propionic acid benzyl ester

: 135727-11-6
(S)-5-Cyclohexyl-2,2-difluoro-4-{(S)-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-3-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-yl]-propionylamino}-3-oxo-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / DMAP / CH₂Cl₂ / 4 h / -20 °C

2: 84 percent / aq. KOH / methanol / 3.5 h / Ambient temperature

3: 28 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC), Et₃N / dimethylformamide / 0 - 20 °C

4: 91 percent / HCl (gas) / CH₂Cl₂; methanol / Ambient temperature

5: 54 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 0 - 20 °C

6: 84 percent / Cl₂HCCO₂H, dicyclohexylcarbodiimide (DCC) / CH₂Cl₂; dimethylsulfoxide / 18 h / Ambient temperature

With hydrogenchloride; dichloro-acetic acid; dmap; potassium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a006

Reference yield:

: 124278-39-3
N-(4-MorpholinYlsulfonyl)-L-phenylalanine

: 135727-11-6
(S)-5-Cyclohexyl-2,2-difluoro-4-{(S)-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-3-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-yl]-propionylamino}-3-oxo-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 0 - 20 °C

2: 84 percent / Cl₂HCCO₂H, dicyclohexylcarbodiimide (DCC) / CH₂Cl₂; dimethylsulfoxide / 18 h / Ambient temperature

With dichloro-acetic acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a006