{(R)-5-[(4,6-Dimethyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-yl}-carbamic acid methyl ester

Base Information

Chemical Name:{(R)-5-[(4,6-Dimethyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-yl}-carbamic acid methyl ester
CAS No.:256397-34-9
Molecular Formula:C₂₇H₂₅F₃N₂O₃
Molecular Weight:482.502
Hs Code.:

Synonyms:{(R)-5-[(4,6-Dimethyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-yl}-carbamic acid methyl ester

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Chemical Property of {(R)-5-[(4,6-Dimethyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-yl}-carbamic acid methyl ester

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Technology Process of {(R)-5-[(4,6-Dimethyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-yl}-carbamic acid methyl ester

There total 4 articles about {(R)-5-[(4,6-Dimethyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-yl}-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 256397-34-9
{(R)-5-[(4,6-Dimethyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-yl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: PdCl₂(dppf); K₃PO₄ / 1,2-dimethoxy-ethane / 16 h / Heating

2: 1 N aq. NaOH / ethanol / 5 h / Heating

3: oxalyl chloride; DMF / CH₂Cl₂ / 16 h / 20 °C

4: pyridine / CH₂Cl₂ / 0.25 h

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydroxide; potassium phosphate; oxalyl dichloride; N,N-dimethyl-formamide; In 1,2-dimethoxyethane; ethanol; dichloromethane; 1: Suzuki coupling;
DOI:10.1021/jm010294e

Reference yield:

: methyl 2-bromo-3,5-dimethylbenzoate

: 256397-34-9
{(R)-5-[(4,6-Dimethyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-yl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: PdCl₂(dppf); K₃PO₄ / 1,2-dimethoxy-ethane / 16 h / Heating

2: 1 N aq. NaOH / ethanol / 5 h / Heating

3: oxalyl chloride; DMF / CH₂Cl₂ / 16 h / 20 °C

4: pyridine / CH₂Cl₂ / 0.25 h

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydroxide; potassium phosphate; oxalyl dichloride; N,N-dimethyl-formamide; In 1,2-dimethoxyethane; ethanol; dichloromethane; 1: Suzuki coupling;
DOI:10.1021/jm010294e

Reference yield:

: 4,6-dimethyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid methyl ester

: 256397-34-9
{(R)-5-[(4,6-Dimethyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-yl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1 N aq. NaOH / ethanol / 5 h / Heating

2: oxalyl chloride; DMF / CH₂Cl₂ / 16 h / 20 °C

3: pyridine / CH₂Cl₂ / 0.25 h

With pyridine; sodium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In ethanol; dichloromethane;
DOI:10.1021/jm010294e