(3S,4R,αS)-N(1)-(α-methylbenzyl)-3-(prop-2′-en-1′-yl)-4-phenylazetidin-2-one

Base Information

Chemical Name:(3S,4R,αS)-N(1)-(α-methylbenzyl)-3-(prop-2′-en-1′-yl)-4-phenylazetidin-2-one
CAS No.:1596359-38-4
Molecular Formula:C₂₀H₂₁NO
Molecular Weight:291.393
Hs Code.:

Synonyms:(3S,4R,αS)-N(1)-(α-methylbenzyl)-3-(prop-2′-en-1′-yl)-4-phenylazetidin-2-one

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Chemical Property of (3S,4R,αS)-N(1)-(α-methylbenzyl)-3-(prop-2′-en-1′-yl)-4-phenylazetidin-2-one

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Technology Process of (3S,4R,αS)-N(1)-(α-methylbenzyl)-3-(prop-2′-en-1′-yl)-4-phenylazetidin-2-one

There total 7 articles about (3S,4R,αS)-N(1)-(α-methylbenzyl)-3-(prop-2′-en-1′-yl)-4-phenylazetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1596359-37-3
methyl (2S,3R,αS)-2-(prop-2′-en-1′-yl)-3-[N-(α-methyl-benzyl)-amino]-3-phenylpropanoate

: 1596359-38-4
(3S,4R,αS)-N(1)-(α-methylbenzyl)-3-(prop-2′-en-1′-yl)-4-phenylazetidin-2-one

Guidance literature:: With methylmagnesium bromide; In diethyl ether; at 0 ℃; for 0.5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1039/c4ob00274a

Reference yield:

: 1596359-34-0
C₂₇H₂₉NO₂

: 1596359-38-4
(3S,4R,αS)-N(1)-(α-methylbenzyl)-3-(prop-2′-en-1′-yl)-4-phenylazetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 48 h / 0 - 50 °C / Inert atmosphere

2: ammonium cerium (IV) nitrate / water; acetonitrile / 16 h / 20 °C / Inert atmosphere

3: methylmagnesium bromide / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

With thionyl chloride; ammonium cerium (IV) nitrate; methylmagnesium bromide; In diethyl ether; water; acetonitrile;
DOI:10.1039/c4ob00274a

Reference yield:

: 1596359-36-2
methyl (2S,3R,αS)-2-(prop-2′-en-1′-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate

: 1596359-38-4
(3S,4R,αS)-N(1)-(α-methylbenzyl)-3-(prop-2′-en-1′-yl)-4-phenylazetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium cerium (IV) nitrate / water; acetonitrile / 16 h / 20 °C / Inert atmosphere

2: methylmagnesium bromide / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

With ammonium cerium (IV) nitrate; methylmagnesium bromide; In diethyl ether; water; acetonitrile;
DOI:10.1039/c4ob00274a