2-[3-((S)-6-Amino-7-hydroxy-heptyl)-benzyl]-malonic acid monomethyl ester

Base Information

• Chemical Name: 2-[3-((S)-6-Amino-7-hydroxy-heptyl)-benzyl]-malonic acid monomethyl ester
• CAS No.: 1027834-53-2
• Molecular Formula: C₁₈H₂₇NO₅
• Molecular Weight: 337.416
• Mol file: 1027834-53-2.mol

Synonyms:2-[3-((S)-6-Amino-7-hydroxy-heptyl)-benzyl]-malonic acid monomethyl ester

Chemical Property of 2-[3-((S)-6-Amino-7-hydroxy-heptyl)-benzyl]-malonic acid monomethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-((S)-6-Amino-7-hydroxy-heptyl)-benzyl]-malonic acid monomethyl ester

There total 5 articles about 2-[3-((S)-6-Amino-7-hydroxy-heptyl)-benzyl]-malonic acid monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-[(E)-5-(3-Formyl-phenyl)-pent-2-enyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester → 2-[3-((S)-6-Amino-7-hydroxy-heptyl)-benzyl]-malonic acid monomethyl ester (1027834-53-2)

Guidance literature:

Multi-step reaction with 3 steps

1: benzoic acid, piperidine / toluene / Heating

2: H₂ / 10percent Pd/C / ethyl acetate

3: HCl(gas) / CH₂Cl₂ / Ambient temperature

With piperidine; hydrogenchloride; hydrogen; benzoic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate; toluene;

DOI:10.1021/jm960583g

Reference yield:

(S)-4-[(E)-5-(3-Bromo-phenyl)-pent-2-enyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester → 2-[3-((S)-6-Amino-7-hydroxy-heptyl)-benzyl]-malonic acid monomethyl ester (1027834-53-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) THF, from -78 to 0 deg C, 1 h

2: benzoic acid, piperidine / toluene / Heating

3: H₂ / 10percent Pd/C / ethyl acetate

4: HCl(gas) / CH₂Cl₂ / Ambient temperature

With piperidine; hydrogenchloride; n-butyllithium; hydrogen; benzoic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate; toluene;

DOI:10.1021/jm960583g

Reference yield:

[3-(3-Bromo-phenyl)-propyl]-triphenyl-phosphonium; iodide → 2-[3-((S)-6-Amino-7-hydroxy-heptyl)-benzyl]-malonic acid monomethyl ester (1027834-53-2)

Guidance literature:

Multi-step reaction with 5 steps

1: t-BuOK / CH₂Cl₂; tetrahydrofuran / 0 °C

2: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) THF, from -78 to 0 deg C, 1 h

3: benzoic acid, piperidine / toluene / Heating

4: H₂ / 10percent Pd/C / ethyl acetate

5: HCl(gas) / CH₂Cl₂ / Ambient temperature

With piperidine; hydrogenchloride; n-butyllithium; potassium tert-butylate; hydrogen; benzoic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;

DOI:10.1021/jm960583g