2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 3-(2-methoxy-3,6-bis-methoxymethoxy-5-nitro-phenyl)-propyl ester

Base Information

Chemical Name:2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 3-(2-methoxy-3,6-bis-methoxymethoxy-5-nitro-phenyl)-propyl ester
CAS No.:913623-01-5
Molecular Formula:C₂₆H₃₂ClNO₁₃
Molecular Weight:601.992
Hs Code.:

Synonyms:2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 3-(2-methoxy-3,6-bis-methoxymethoxy-5-nitro-phenyl)-propyl ester

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Chemical Property of 2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 3-(2-methoxy-3,6-bis-methoxymethoxy-5-nitro-phenyl)-propyl ester

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Technology Process of 2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 3-(2-methoxy-3,6-bis-methoxymethoxy-5-nitro-phenyl)-propyl ester

There total 11 articles about 2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 3-(2-methoxy-3,6-bis-methoxymethoxy-5-nitro-phenyl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-chloro-4,6-dihydroxy-2-(5-oxo-pentyl)-benzoic acid 3-(2-methoxy-3,6-bis-methoxymethoxy-5-nitro-phenyl)-propyl ester

: 913623-01-5
2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 3-(2-methoxy-3,6-bis-methoxymethoxy-5-nitro-phenyl)-propyl ester

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 0.5h;
DOI:10.1021/jo061054f

Reference yield:

: 913622-68-1
ethyl 3-(2-methoxy-3,6-bis(methoxymethoxy)phenyl)acrylate

: 913623-01-5
2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 3-(2-methoxy-3,6-bis-methoxymethoxy-5-nitro-phenyl)-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / Pd/C / ethyl acetate / 12 h

1.2: 3.69 g / DIBAL-H / CH₂Cl₂ / 1 h / 0 °C

2.1: NH₄NO₃; (CF₃CO)2O / acetonitrile / 0.25 h / 20 °C

2.2: 67 percent / LiOH / tetrahydrofuran; methanol; H₂O / 0.08 h

3.1: 82 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 10 h / 0 - 20 °C

4.1: OsO₄; NaIO₄; 2,6-lutidine / dioxane; H₂O / 2 h / 20 °C

5.1: 313 mg / 2-methyl-2-butene; NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 0.5 h / 20 °C

With ammonium nitrate; 2,6-dimethylpyridine; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; acetonitrile; tert-butyl alcohol; 3.1: Mitsunobu esterification;
DOI:10.1021/jo061054f

Reference yield:

: 824-46-4
methoxyhydroquinone

: 913623-01-5
2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 3-(2-methoxy-3,6-bis-methoxymethoxy-5-nitro-phenyl)-propyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 91 percent / NaH

2.1: TMEDA; n-BuLi / tetrahydrofuran / 4 h / 20 °C

2.2: 77 percent / tetrahydrofuran / 2 h

3.1: NaH / toluene / 0.25 h / 20 °C

3.2: 86 percent / toluene / 12 h / 20 °C

4.1: H₂ / Pd/C / ethyl acetate / 12 h

4.2: 3.69 g / DIBAL-H / CH₂Cl₂ / 1 h / 0 °C

5.1: NH₄NO₃; (CF₃CO)2O / acetonitrile / 0.25 h / 20 °C

5.2: 67 percent / LiOH / tetrahydrofuran; methanol; H₂O / 0.08 h

6.1: 82 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 10 h / 0 - 20 °C

7.1: OsO₄; NaIO₄; 2,6-lutidine / dioxane; H₂O / 2 h / 20 °C

8.1: 313 mg / 2-methyl-2-butene; NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 0.5 h / 20 °C

With ammonium nitrate; 2,6-dimethylpyridine; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; n-butyllithium; 2-methyl-but-2-ene; N,N,N,N,-tetramethylethylenediamine; di-isopropyl azodicarboxylate; hydrogen; sodium hydride; triphenylphosphine; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; toluene; acetonitrile; tert-butyl alcohol; 6.1: Mitsunobu esterification;
DOI:10.1021/jo061054f