2-chloro-6-(difluoro(3-nitrophenyl)methyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

Base Information

Chemical Name:2-chloro-6-(difluoro(3-nitrophenyl)methyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine
CAS No.:1447216-85-4
Molecular Formula:C₁₇H₁₄ClF₂N₅O₃
Molecular Weight:409.78
Hs Code.:

Synonyms:2-chloro-6-(difluoro(3-nitrophenyl)methyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

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Chemical Property of 2-chloro-6-(difluoro(3-nitrophenyl)methyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

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Technology Process of 2-chloro-6-(difluoro(3-nitrophenyl)methyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

There total 4 articles about 2-chloro-6-(difluoro(3-nitrophenyl)methyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1447216-83-2
(2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)(3-nitrophenyl)methanone

: 1447216-85-4
2-chloro-6-(difluoro(3-nitrophenyl)methyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 20419-68-5
2,6-dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 1447216-85-4
2-chloro-6-(difluoro(3-nitrophenyl)methyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride; 1,3-dimethylimidazolim iodide / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 20 °C / Inert atmosphere

With diethylamino-sulfur trifluoride; sodium hydride; 1,3-dimethylimidazolim iodide; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 5451-40-1
2,6 dichloropurine

: 1447216-85-4
2-chloro-6-(difluoro(3-nitrophenyl)methyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / dichloromethane / 6 h / 20 °C

2: sodium hydride; 1,3-dimethylimidazolim iodide / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

3: diethylamino-sulfur trifluoride / dichloromethane / 20 °C / Inert atmosphere

With diethylamino-sulfur trifluoride; sodium hydride; 1,3-dimethylimidazolim iodide; toluene-4-sulfonic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;