2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINE

Base Information

• Chemical Name: 2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINE
• CAS No.: 635713-68-7
• Molecular Formula: C12H15 N3 O
• Molecular Weight: 217.27
• Hs Code.: 2933990090
• Mol file: 635713-68-7.mol

Synonyms:spiro[1,3-dihydroquinazoline-4,4'-piperidine]-2-one;

Chemical Property of 2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINE

Chemical Property:

• Boiling Point: 371.3±42.0 °C(Predicted)
• PKA: 11.77±0.20(Predicted)
• Flash Point: 153.612oC
• PSA: 56.65000
• Density: 1.26±0.1 g/cm3(Predicted)
• LogP: 1.50720
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

1''H-Spiro[piperidine-4,4''-quinazolin]-2''(3''H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINE

There total 4 articles about 2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-benzyl-2',3'-dihydro-2'-oxospiro-[piperidine-4,4'(1'H)-quinazoline] (635713-67-6) → 2',3'-dihydro-2'-oxospiro-[piperidine-4,4'(1'H)-quinazoline] (635713-68-7)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; for 12h; under 760.051 Torr;

DOI:10.1016/j.bmcl.2012.05.118

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 2',3'-dihydro-2'-oxospiro-[piperidine-4,4'(1'H)-quinazoline] (635713-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1: polyphosphoric acid / 3 h / 100 °C

2: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol / 12 h / 760.05 Torr

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol;

DOI:10.1016/j.bmcl.2012.05.118

Reference yield:

phenyl carbamate (64-10-8) → 2',3'-dihydro-2'-oxospiro-[piperidine-4,4'(1'H)-quinazoline] (635713-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1: polyphosphoric acid / 3 h / 100 °C

2: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol / 12 h / 760.05 Torr

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol;

DOI:10.1016/j.bmcl.2012.05.118

upstream raw materials:

1-benzyl-2',3'-dihydro-2'-oxospiro-[piperidine-4,4'(1'H)-quinazoline]

1-phenylmethyl-4-piperidone

phenyl carbamate