5’-O-tosyluridine

Base Information

• Chemical Name: 5’-O-tosyluridine
• CAS No.: 24380-35-6
• Molecular Formula: C₁₆H₁₈N₂O₈S
• Molecular Weight: 398.394
• Mol file: 24380-35-6.mol

Synonyms:5’-O-tosyluridine

Chemical Property of 5’-O-tosyluridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5’-O-tosyluridine

There total 7 articles about 5’-O-tosyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2',3'-O-(methoxymethylidene)-5'-O-tosyluridine (1167433-42-2) → 5’-O-tosyluridine (24380-35-6)

Guidance literature:

With hydrogenchloride; In acetonitrile; for 1h;

DOI:10.1021/jo00385a026

Reference yield: 71.0%

2',3'-O-isopropylidene-5'-O-tosyluridine (7354-93-0) → 5’-O-tosyluridine (24380-35-6)

Guidance literature:

With trifluoroacetic acid; In water; for 0.166667h;

DOI:10.3762/bjoc.11.52

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 5’-O-tosyluridine (24380-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-(N,N-dimethylamino)pyridine (4-DMAP) / CH₂Cl₂ / 24 h

2: 87 percent / aq. HCl / acetonitrile / 1 h

With hydrogenchloride; dmap; In dichloromethane; acetonitrile;

DOI:10.1021/jo00385a026

upstream raw materials:

2',3'-O-isopropylidene-5'-O-tosyluridine

2',3'-O-(methoxymethylidene)-5'-O-tosyluridine

p-toluenesulfonyl chloride

uridine

Downstream raw materials:

UDP

Refernces

• 1、 Davisson, V. Jo,Davis, Darrell R.,Dixit, Vyas M.,Poulter, C. Dale. "Synthesis of Nucleotide 5'-Diphosphates from 5'-O-Tosyl Nucleosides". . p. 1794 - 1801. Retrieved 2007/10/02.