Biphenyl-4-carboxylic acid [(2R,3S,4R,5S,6S,7R,9R,10R,11S,12S,13R)-10-((2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,9,12-tetrahydroxy-3,5,7,9,11,13-hexamethyl-14-oxo-oxacyclotetradec-6-yl]-amide

Base Information

Chemical Name:Biphenyl-4-carboxylic acid [(2R,3S,4R,5S,6S,7R,9R,10R,11S,12S,13R)-10-((2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,9,12-tetrahydroxy-3,5,7,9,11,13-hexamethyl-14-oxo-oxacyclotetradec-6-yl]-amide
CAS No.:78443-18-2
Molecular Formula:C₄₂H₆₄N₂O₁₀
Molecular Weight:756.978
Hs Code.:

Biphenyl-4-carboxylic acid [(2R,3S,4R,5S,6S,7R,9R,10R,11S,12S,13R)-10-((2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,9,12-tetrahydroxy-3,5,7,9,11,13-hexamethyl-14-oxo-oxacyclotetradec-6-yl]-amide

Synonyms:Biphenyl-4-carboxylic acid [(2R,3S,4R,5S,6S,7R,9R,10R,11S,12S,13R)-10-((2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,9,12-tetrahydroxy-3,5,7,9,11,13-hexamethyl-14-oxo-oxacyclotetradec-6-yl]-amide

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Chemical Property of Biphenyl-4-carboxylic acid [(2R,3S,4R,5S,6S,7R,9R,10R,11S,12S,13R)-10-((2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,9,12-tetrahydroxy-3,5,7,9,11,13-hexamethyl-14-oxo-oxacyclotetradec-6-yl]-amide

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Technology Process of Biphenyl-4-carboxylic acid [(2R,3S,4R,5S,6S,7R,9R,10R,11S,12S,13R)-10-((2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,9,12-tetrahydroxy-3,5,7,9,11,13-hexamethyl-14-oxo-oxacyclotetradec-6-yl]-amide

There total 4 articles about Biphenyl-4-carboxylic acid [(2R,3S,4R,5S,6S,7R,9R,10R,11S,12S,13R)-10-((2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,9,12-tetrahydroxy-3,5,7,9,11,13-hexamethyl-14-oxo-oxacyclotetradec-6-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 449142-84-1
C₄₄H₆₆N₂O₁₂

: 78443-18-2
Biphenyl-4-carboxylic acid [(2R,3S,4R,5S,6S,7R,9R,10R,11S,12S,13R)-10-((2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,9,12-tetrahydroxy-3,5,7,9,11,13-hexamethyl-14-oxo-oxacyclotetradec-6-yl]-amide

Guidance literature:: With methanol; Yield given;
DOI:10.1021/ja00401a051

Reference yield:

: C₅₄H₈₂N₂O₁₆

: 78443-18-2
Biphenyl-4-carboxylic acid [(2R,3S,4R,5S,6S,7R,9R,10R,11S,12S,13R)-10-((2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,9,12-tetrahydroxy-3,5,7,9,11,13-hexamethyl-14-oxo-oxacyclotetradec-6-yl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: MeOH

2: 75 percent / Na-Hg/MeOH

3: 1.) HCl, MeOH, 2.) Et₃N, aq. NaHCO₃ / 1.) 25 deg C, 2.) CH₂Cl₂, 25 deg C

With hydrogenchloride; methanol; sodium amalgam; sodium hydrogencarbonate; triethylamine;
DOI:10.1021/ja00401a051

Reference yield:

: 78443-21-7
C₅₂H₈₀N₂O₁₄

: 78443-18-2
Biphenyl-4-carboxylic acid [(2R,3S,4R,5S,6S,7R,9R,10R,11S,12S,13R)-10-((2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,9,12-tetrahydroxy-3,5,7,9,11,13-hexamethyl-14-oxo-oxacyclotetradec-6-yl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / Na-Hg/MeOH

2: 1.) HCl, MeOH, 2.) Et₃N, aq. NaHCO₃ / 1.) 25 deg C, 2.) CH₂Cl₂, 25 deg C

With hydrogenchloride; methanol; sodium amalgam; sodium hydrogencarbonate; triethylamine;
DOI:10.1021/ja00401a051