3(R)-[[[1-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]carbonyl]amino]-3-benzyl-2-oxo-1-pyrrolidineacetamide

Base Information

Chemical Name:3(R)-[[[1-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]carbonyl]amino]-3-benzyl-2-oxo-1-pyrrolidineacetamide
CAS No.:501380-94-5
Molecular Formula:C₂₃H₃₂N₄O₅
Molecular Weight:444.531
Hs Code.:

Synonyms:3(R)-[[[1-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]carbonyl]amino]-3-benzyl-2-oxo-1-pyrrolidineacetamide

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Chemical Property of 3(R)-[[[1-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]carbonyl]amino]-3-benzyl-2-oxo-1-pyrrolidineacetamide

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Technology Process of 3(R)-[[[1-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]carbonyl]amino]-3-benzyl-2-oxo-1-pyrrolidineacetamide

There total 2 articles about 3(R)-[[[1-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]carbonyl]amino]-3-benzyl-2-oxo-1-pyrrolidineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 501380-91-2
methyl 3(R)-[[[1-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]carbonyl]amino]-3-benzyl-2-oxo-1-pyrrolidineacetate

: 501380-94-5
3(R)-[[[1-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]carbonyl]amino]-3-benzyl-2-oxo-1-pyrrolidineacetamide

Guidance literature:: With ammonia;
DOI:10.1021/jm020441o

Reference yield:

: methyl 3(R)-[N-(tert-butoxycarbonyl)amino]-3-benzyl-2-oxo-1-pyrrolidineacetate hydrochloride

: 501380-94-5
3(R)-[[[1-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]carbonyl]amino]-3-benzyl-2-oxo-1-pyrrolidineacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 0.97 g / HOBt; EDC*HCl; Et₃N / CH₂Cl₂; dimethylformamide / 20 °C

2: 62 percent / conc. methanolic ammonia

With ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020441o