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Technology Process of Apilimod

Apilimod

Base Information
  • Chemical Name:Apilimod
  • CAS No.:541550-19-0
  • Molecular Formula:C23H26 N6 O2
  • Molecular Weight:418.49
  • Hs Code.:
  • European Community (EC) Number:810-045-5
  • UNII:GFW2K84S4L
  • Wikipedia:Apilimod
  • NCI Thesaurus Code:C90808
  • Pharos Ligand ID:XRFZJMW23JHV
  • Metabolomics Workbench ID:149527
  • ChEMBL ID:CHEMBL4297643
  • Mol file:541550-19-0.mol
Apilimod

Synonyms:apilimod;apilimod bis-mesylate;apilimod bismesylate;apilimod dimesylate;apilimod mesilate;apilimod mesylate;STA 5326;STA 5326 mesilate;STA 5326 mesylate;STA-5326;STA-5326 mesilate;STA-5326 mesylate;STA5326

Suppliers and Price of Apilimod
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • DC Chemicals
  • Apilimod >98%
  • 1 g
  • $ 1900.00
  • DC Chemicals
  • Apilimod >98%
  • 250 mg
  • $ 1100.00
  • DC Chemicals
  • Apilimod >98%
  • 100 mg
  • $ 650.00
  • ChemScene
  • Apilimod 99.61%
  • 50mg
  • $ 120.00
  • ChemScene
  • Apilimod 99.61%
  • 10mg
  • $ 80.00
  • ChemScene
  • Apilimod 99.61%
  • 5mg
  • $ 50.00
  • ChemScene
  • Apilimod 99.61%
  • 100mg
  • $ 520.00
  • Biosynth Carbosynth
  • Apilimod NEW
  • 50 mg
  • $ 500.00
  • Biosynth Carbosynth
  • Apilimod NEW
  • 25 mg
  • $ 387.50
  • Biosynth Carbosynth
  • Apilimod NEW
  • 250 mg
  • $ 917.50
Total 31 raw suppliers
Chemical Property of Apilimod
Chemical Property:
  • Boiling Point:655.1±65.0 °C(Predicted) 
  • PKA:12.56±0.10(Predicted) 
  • PSA：84.76000 
  • Density:1.24 
  • LogP:3.22210 
  • Storage Temp.:-20°C 
  • Solubility.:Soluble in DMSO (>25 mg/ml) 
  • XLogP3:3.8
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:8
  • Rotatable Bond Count:8
  • Exact Mass:418.21172409
  • Heavy Atom Count:31
  • Complexity:544
Purity/Quality:

99%, *data from raw suppliers

Apilimod >98% *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC1=CC(=CC=C1)C=NNC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4
  • Isomeric SMILES:CC1=CC(=CC=C1)/C=N/NC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4
  • Recent ClinicalTrials:The Immunological and Blood Effects of STA-5326 Mesylate on Patients With Crohn's Disease
  • Description Apilimod (541550-19-0) is a potent (IC50 = 10 nM IFN-g/LPS-stimulated human PMBC’s; IC50 = 1 nM in IFN-g/SAC-stimulated human PMBC’s) IL-12/IL-23 inhibitor downregulating both at the transcriptional level.? Suppresses Th1 but not Th2 immune response.1? Inhibition was also observed in human monocytes, monocyte-derived dendritic cells, and THP-1 cells.? Apilimod’s mechanism of action is mediation of TLR signaling via inhibition of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve; IC50 = 14 nM).2? It displayed selective cytotoxic activity in B-cell non-Hodgkin lymphoma compared with normal cells.3? Apilimod prevented infection of VSV-ZEBOV and VSV-SARS-CoV-2 (IC50 = 50 nM) as well as SARS-CoV-2 strain 2019-nCoVB/USA-1WA/2020.4
  • Uses Apilimod is a small-molecule that selectively suppresses synthesis of IL-12 and IL-23. Apilimod reduces dendritic cell infiltration in psoriasis.
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