N-(3-(dimethylamino)propyl)-2-(4-(4-(4-(4-((3-(piperidin-1-yl)propyl)carbamoyl)oxazol-2-yl)phenyl)-1,2,3-triazol-1-yl)phenyl)oxazole-4-carboxamide

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Chemical Name:N-(3-(dimethylamino)propyl)-2-(4-(4-(4-(4-((3-(piperidin-1-yl)propyl)carbamoyl)oxazol-2-yl)phenyl)-1,2,3-triazol-1-yl)phenyl)oxazole-4-carboxamide
CAS No.:1353130-87-6
Molecular Formula:C₃₅H₄₁N₉O₄
Molecular Weight:651.768
Hs Code.:

Synonyms:N-(3-(dimethylamino)propyl)-2-(4-(4-(4-(4-((3-(piperidin-1-yl)propyl)carbamoyl)oxazol-2-yl)phenyl)-1,2,3-triazol-1-yl)phenyl)oxazole-4-carboxamide

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Chemical Property of N-(3-(dimethylamino)propyl)-2-(4-(4-(4-(4-((3-(piperidin-1-yl)propyl)carbamoyl)oxazol-2-yl)phenyl)-1,2,3-triazol-1-yl)phenyl)oxazole-4-carboxamide

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Technology Process of N-(3-(dimethylamino)propyl)-2-(4-(4-(4-(4-((3-(piperidin-1-yl)propyl)carbamoyl)oxazol-2-yl)phenyl)-1,2,3-triazol-1-yl)phenyl)oxazole-4-carboxamide

There total 11 articles about N-(3-(dimethylamino)propyl)-2-(4-(4-(4-(4-((3-(piperidin-1-yl)propyl)carbamoyl)oxazol-2-yl)phenyl)-1,2,3-triazol-1-yl)phenyl)oxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1353130-65-0
N-(3-(dimethylamino)propyl)-2-(4-azidophenyl)oxazole-4-carboxamide

: 1353130-53-6
N-(3-(piperidin-1-yl)propyl)-2-(4-ethynylphenyl)oxazole-4-carboxamide

: 1353130-87-6
N-(3-(dimethylamino)propyl)-2-(4-(4-(4-(4-((3-(piperidin-1-yl)propyl)carbamoyl)oxazol-2-yl)phenyl)-1,2,3-triazol-1-yl)phenyl)oxazole-4-carboxamide

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 100 ℃; for 0.416667h; Microwave irradiation;
DOI:10.1016/j.tet.2011.10.066

Reference yield:

: 2-(4-ethynylphenyl)oxazole-4-carbonyl chloride

: 1353130-87-6
N-(3-(dimethylamino)propyl)-2-(4-(4-(4-(4-((3-(piperidin-1-yl)propyl)carbamoyl)oxazol-2-yl)phenyl)-1,2,3-triazol-1-yl)phenyl)oxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 0 - 20 °C / Inert atmosphere

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 0.42 h / 100 °C / Microwave irradiation

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.tet.2011.10.066

Reference yield:

: 863640-43-1
4-(trimethylsilanylethynyl)benzamide

: 1353130-87-6
N-(3-(dimethylamino)propyl)-2-(4-(4-(4-(4-((3-(piperidin-1-yl)propyl)carbamoyl)oxazol-2-yl)phenyl)-1,2,3-triazol-1-yl)phenyl)oxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran / Reflux; Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; water / 2 h / 50 °C

2.2: pH 2

3.1: oxalyl dichloride / tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

4.1: dichloromethane / 0 - 20 °C / Inert atmosphere

5.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 0.42 h / 100 °C / Microwave irradiation

With copper(ll) sulfate pentahydrate; oxalyl dichloride; sodium hydrogencarbonate; sodium L-ascorbate; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: Blümlein-Lewy oxazole synthesis;
DOI:10.1016/j.tet.2011.10.066