9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(4-fluoro-phenoxy)-3,9-dihydro-purin-2-one

Base Information

Chemical Name:9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(4-fluoro-phenoxy)-3,9-dihydro-purin-2-one
CAS No.:195611-68-8
Molecular Formula:C₂₈H₄₃FN₄O₅Si₂
Molecular Weight:590.843
Hs Code.:

9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(4-fluoro-phenoxy)-3,9-dihydro-purin-2-one

Synonyms:9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(4-fluoro-phenoxy)-3,9-dihydro-purin-2-one

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Chemical Property of 9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(4-fluoro-phenoxy)-3,9-dihydro-purin-2-one

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Technology Process of 9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(4-fluoro-phenoxy)-3,9-dihydro-purin-2-one

There total 3 articles about 9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(4-fluoro-phenoxy)-3,9-dihydro-purin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 195611-66-6
9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(4-fluoro-phenoxy)-9H-purin-2-ylamine

: 195611-68-8
9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(4-fluoro-phenoxy)-3,9-dihydro-purin-2-one

Guidance literature:: With acetic acid; sodium nitrite; In water; acetone; for 3h; Ambient temperature;
DOI:10.1055/s-1997-952

Reference yield:

: 371-41-5
4-Fluorophenol

: 195611-68-8
9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(4-fluoro-phenoxy)-3,9-dihydro-purin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) trifluoracetic anhydride, pyridine, 2.) pyridine, 3.) K₂CO₃, H₂O / 1.) 25 min, 0 deg C, 2.) 2 h, 0 deg C; 48 h, room temp., 3.) MeOH, 3 h, room temp.

2: 60 percent / NaNO₂, acetic acid / acetone; H₂O / 3 h / Ambient temperature

With pyridine; water; potassium carbonate; acetic acid; trifluoroacetic anhydride; sodium nitrite; In water; acetone;
DOI:10.1055/s-1997-952

Reference yield:

: 51549-35-0
3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

: 195611-68-8
9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(4-fluoro-phenoxy)-3,9-dihydro-purin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) trifluoracetic anhydride, pyridine, 2.) pyridine, 3.) K₂CO₃, H₂O / 1.) 25 min, 0 deg C, 2.) 2 h, 0 deg C; 48 h, room temp., 3.) MeOH, 3 h, room temp.

2: 60 percent / NaNO₂, acetic acid / acetone; H₂O / 3 h / Ambient temperature

With pyridine; water; potassium carbonate; acetic acid; trifluoroacetic anhydride; sodium nitrite; In water; acetone;
DOI:10.1055/s-1997-952