4-(6-(4-((6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)phenoxy)hexyl)morpholine

Base Information

Chemical Name:4-(6-(4-((6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)phenoxy)hexyl)morpholine
CAS No.:1609169-49-4
Molecular Formula:C₂₈H₄₀N₂O₄
Molecular Weight:468.637
Hs Code.:

Synonyms:4-(6-(4-((6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)phenoxy)hexyl)morpholine

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Chemical Property of 4-(6-(4-((6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)phenoxy)hexyl)morpholine

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Technology Process of 4-(6-(4-((6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)phenoxy)hexyl)morpholine

There total 10 articles about 4-(6-(4-((6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)phenoxy)hexyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

: 1609169-81-4
tert-butyl 6,7-dimethoxy-1-(4-((6-morpholinohexyl)oxy)benzyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1609169-49-4
4-(6-(4-((6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)phenoxy)hexyl)morpholine

Guidance literature:: With hydrogenchloride; In diethyl ether; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2014.03.058

Reference yield:

: 1609169-64-3
tert-butyl 1-(4-((6-bromohexyl)oxy)benzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1609169-49-4
4-(6-(4-((6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)phenoxy)hexyl)morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 60 °C

2: hydrogenchloride / diethyl ether / 3 h / 20 °C

With hydrogenchloride; sodium hydrogencarbonate; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.03.058

Reference yield:

: 10214-84-3
N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(4-hydroxyphenyl)acetamide

: 1609169-49-4
4-(6-(4-((6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)phenoxy)hexyl)morpholine

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate / ethanol / 12 h / Reflux

2: trichlorophosphate / toluene / 4 h / 20 °C / Reflux

3: sodium tetrahydroborate / methanol / 6 h / 0 - 20 °C

4: dichloromethane / 2 h / 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 48 h

6: potassium carbonate / butanone / 6 h / Reflux

7: sodium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 60 °C

8: hydrogenchloride / diethyl ether / 3 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; potassium carbonate; trichlorophosphate; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; butanone; 2: |Bischler-Napieralski Reaction;
DOI:10.1016/j.bmcl.2014.03.058