1-(3,4-dichlorobenzyl)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)urea

Base Information

• Chemical Name: 1-(3,4-dichlorobenzyl)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)urea
• CAS No.: 1227092-25-2
• Molecular Formula: C₁₈H₂₀Cl₂N₄O
• Molecular Weight: 379.289

Synonyms:1-(3,4-dichlorobenzyl)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)urea

Chemical Property of 1-(3,4-dichlorobenzyl)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)urea

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Technology Process of 1-(3,4-dichlorobenzyl)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)urea

There total 1 articles about 1-(3,4-dichlorobenzyl)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethanamine hydrochloride (1227095-56-8) + 1,2-dichloro-4-isocyanatomethylbenzene (19752-09-1) → 1-(3,4-dichlorobenzyl)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)urea (1227092-25-2)

Guidance literature:

With resin-bound diisopropylethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield: 76.0%

1-(3,4-dichlorobenzyl)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)urea (1227092-25-2) + acetic anhydride (108-24-7) → 1-(2-(8-acetyl-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)-3-(3,4-dichlorobenzyl)urea (1227094-80-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere; Reflux;

Reference yield: 71.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-(3,4-dichlorobenzyl)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)urea (1227092-25-2) → 1-(3,4-dichIorobenzyI)-3-(2-(8-methyl-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)urea (1227094-79-2)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; water; at 20 ℃; for 3h; Inert atmosphere;

upstream raw materials:

2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethanamine hydrochloride

1,2-dichloro-4-isocyanatomethylbenzene

Downstream raw materials:

1-(2-(8-acetyl-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)-3-(3,4-dichlorobenzyl)urea

1-(3,4-dichlorobenzyl)-3-(2-(8-(methylsulfonyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)urea

1-(3,4-dichIorobenzyI)-3-(2-(8-methyl-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)urea

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