(R)-diethyl 2-[(naphthalen-1-yl)methyl]-3-(tetrahydrofuran-2-yl)malonate

Base Information

Chemical Name:(R)-diethyl 2-[(naphthalen-1-yl)methyl]-3-(tetrahydrofuran-2-yl)malonate
CAS No.:1376220-54-0
Molecular Formula:C₂₃H₂₈O₅
Molecular Weight:384.472
Hs Code.:

Synonyms:(R)-diethyl 2-[(naphthalen-1-yl)methyl]-3-(tetrahydrofuran-2-yl)malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-diethyl 2-[(naphthalen-1-yl)methyl]-3-(tetrahydrofuran-2-yl)malonate

Chemical Property:

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Technology Process of (R)-diethyl 2-[(naphthalen-1-yl)methyl]-3-(tetrahydrofuran-2-yl)malonate

There total 3 articles about (R)-diethyl 2-[(naphthalen-1-yl)methyl]-3-(tetrahydrofuran-2-yl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 86-52-2
1-Chloromethylnaphthalene

: 71862-15-2
ethyl (2'R)-2-carboethoxy-3-(tetrahydro-2'-furyl)propanoate

: 1376220-54-0
(R)-diethyl 2-[(naphthalen-1-yl)methyl]-3-(tetrahydrofuran-2-yl)malonate

Guidance literature:: ethyl (2'R)-2-carboethoxy-3-(tetrahydro-2'-furyl)propanoate; With sodium hydride; In N,N-dimethyl-formamide; at 40 ℃;

1-Chloromethylnaphthalene; In N,N-dimethyl-formamide; at 80 ℃; for 3h;
DOI:10.1016/j.bmcl.2012.03.093

Reference yield:

: 97-99-4,22415-59-4,57203-01-7,72074-94-3
(R)-(tetrahydrofuran-2-yl)methanol

: 1376220-54-0
(R)-diethyl 2-[(naphthalen-1-yl)methyl]-3-(tetrahydrofuran-2-yl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 3 h / 0 °C

2.1: sodium ethanolate / 2 h / 20 °C

2.2: 28 h / 20 - 78 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 40 °C

3.2: 3 h / 80 °C

With pyridine; sodium ethanolate; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.03.093

Reference yield:

: 22415-60-7,34583-63-6,114114-90-8
[(2R)-tetrahydrofuran-2-yl]methyl 4-methylbenzenesulfonate

: 1376220-54-0
(R)-diethyl 2-[(naphthalen-1-yl)methyl]-3-(tetrahydrofuran-2-yl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium ethanolate / 2 h / 20 °C

1.2: 28 h / 20 - 78 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 40 °C

2.2: 3 h / 80 °C

With sodium ethanolate; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.03.093