3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)propanoic acid

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Chemical Name:3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)propanoic acid
CAS No.:1447710-97-5
Molecular Formula:C₂₈H₄₀N₂O₅
Molecular Weight:484.636
Hs Code.:

Synonyms:3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)propanoic acid

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Chemical Property of 3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)propanoic acid

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Technology Process of 3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)propanoic acid

There total 11 articles about 3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1447710-95-3
methyl-3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)propanoate

: 1447710-97-5
3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)propanoic acid

Guidance literature:: With lithium hydroxide dihydrate; water; In tetrahydrofuran; at 25 ℃;
DOI:10.1016/j.ejmech.2013.09.015

Reference yield:

: 499-76-3
4-hydroxy-3-methylbenzoic acid

: 1447710-97-5
3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)propanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: sulfuric acid / 6 h / Reflux

2.1: potassium carbonate; potassium iodide / 6 h / Reflux

3.1: diethyl ether / 2 h / 0 - 30 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 25 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

5.2: 2 h / 25 °C

6.1: palladium on activated charcoal; ammonium formate / methanol / 25 °C

7.1: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

8.1: potassium hydroxide; water / ethanol / 5 h / 80 °C

9.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 25 °C

10.1: water; lithium hydroxide dihydrate / tetrahydrofuran / 25 °C

With lithium hydroxide dihydrate; sulfuric acid; palladium on activated charcoal; boron trifluoride diethyl etherate; water; ammonium formate; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2013.09.015

Reference yield:

: 2199-43-1
ethyl 1H-pyrrole-2-carboxylate

: 1447710-97-5
3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 25 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 2 h / 25 °C

3.1: palladium on activated charcoal; ammonium formate / methanol / 25 °C

4.1: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

5.1: potassium hydroxide; water / ethanol / 5 h / 80 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 25 °C

7.1: water; lithium hydroxide dihydrate / tetrahydrofuran / 25 °C

With lithium hydroxide dihydrate; palladium on activated charcoal; boron trifluoride diethyl etherate; water; ammonium formate; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2013.09.015