tert-butyl {(3S)-3-methyl-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidin-3-yl}carbamate

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Chemical Name:tert-butyl {(3S)-3-methyl-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidin-3-yl}carbamate
CAS No.:927393-67-7
Molecular Formula:C₁₈H₂₆N₂O₃
Molecular Weight:318.416
Hs Code.:

Synonyms:tert-butyl {(3S)-3-methyl-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidin-3-yl}carbamate

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Chemical Property of tert-butyl {(3S)-3-methyl-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidin-3-yl}carbamate

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Technology Process of tert-butyl {(3S)-3-methyl-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidin-3-yl}carbamate

There total 1 articles about tert-butyl {(3S)-3-methyl-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidin-3-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 146512-05-2
(3S)-3-methyl-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylic acid

: 927393-67-7
tert-butyl {(3S)-3-methyl-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidin-3-yl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 3.5 h / 20 °C / Reflux

2: toluene / 11 h / Reflux

With diphenyl phosphoryl azide; triethylamine; In toluene;
DOI:10.1248/cpb.59.341

Reference yield: 85.0%

: 927393-67-7
tert-butyl {(3S)-3-methyl-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidin-3-yl}carbamate

: 927393-68-8
tert-butyl {(3S)-3-methyl-1-[(1R)-1-phenylethyl]pyrrolidin-3-yl}carbamate

Guidance literature:: With borane-THF; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1248/cpb.59.341

Reference yield:

: 927393-67-7
tert-butyl {(3S)-3-methyl-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidin-3-yl}carbamate

: 927393-70-2
benzyl (3S)-3-[(tert-butoxycarbonyl)(methyl)amino]-3-methylpyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: borane-THF / tetrahydrofuran / 0 - 20 °C

2: 20 % Pd(OH)2/C; hydrogen / 1,4-dioxane / 5 h / 50 °C

3: sodium hydrogencarbonate / diethyl ether; water / 16 h / 20 °C

4: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C

With borane-THF; 20 % Pd(OH)2/C; hydrogen; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.59.341