(2R,6R,12bS,E)-benzyl 3-ethylidene-2-(2-methoxy-2-oxoethyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine-6-carboxylate

Base Information

Chemical Name:(2R,6R,12bS,E)-benzyl 3-ethylidene-2-(2-methoxy-2-oxoethyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine-6-carboxylate
CAS No.:295788-92-0
Molecular Formula:C₂₈H₃₀N₂O₄
Molecular Weight:458.557
Hs Code.:

Synonyms:(2R,6R,12bS,E)-benzyl 3-ethylidene-2-(2-methoxy-2-oxoethyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine-6-carboxylate

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Chemical Property of (2R,6R,12bS,E)-benzyl 3-ethylidene-2-(2-methoxy-2-oxoethyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine-6-carboxylate

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Technology Process of (2R,6R,12bS,E)-benzyl 3-ethylidene-2-(2-methoxy-2-oxoethyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine-6-carboxylate

There total 20 articles about (2R,6R,12bS,E)-benzyl 3-ethylidene-2-(2-methoxy-2-oxoethyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: (1S,3R)-benzyl 2-((Z)-2-iodobut-2-en-1-yl)-1-((E)-4-methoxy-4-oxobut-2-en-1-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

: 295788-92-0
(2R,6R,12bS,E)-benzyl 3-ethylidene-2-(2-methoxy-2-oxoethyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine-6-carboxylate

Guidance literature:: (1S,3R)-benzyl 2-((Z)-2-iodobut-2-en-1-yl)-1-((E)-4-methoxy-4-oxobut-2-en-1-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate; With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; triethylamine; In acetonitrile; at 20 ℃; for 0.333333h;

With triethylsilane; at 20 ℃; for 2h;
DOI:10.1021/ja0016553

Reference yield: 59.0%

: trans-3-benzyloxycarbonyl-2-(Z-2-iodo-2-butenyl)-1-(3'-methoxycarbonylprop-2-enyl)-1,2,3,4-tetrahydro-9H-pyrido-[3,4-b]indole

: 295788-92-0
(2R,6R,12bS,E)-benzyl 3-ethylidene-2-(2-methoxy-2-oxoethyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine-6-carboxylate

Guidance literature:: With tetrabutyl-ammonium chloride; sodium formate; palladium diacetate; lithium bromide; In N,N-dimethyl-formamide; at 40 ℃; for 12h; Inert atmosphere;
DOI:10.1039/d1ra00015b

Reference yield: 55.0%

: (1S,3R)-benzyl 2-((Z)-2-iodobut-2-en-1-yl)-1-((E)-4-methoxy-4-oxobut-2-en-1-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

: (2S,6R,12bS,E)-benzyl 3-ethylidene-2-(2-methoxy-2-oxoethyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine-6-carboxylate

: 295788-92-0
(2R,6R,12bS,E)-benzyl 3-ethylidene-2-(2-methoxy-2-oxoethyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine-6-carboxylate

Guidance literature:: (1S,3R)-benzyl 2-((Z)-2-iodobut-2-en-1-yl)-1-((E)-4-methoxy-4-oxobut-2-en-1-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate; With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; triethylamine; In acetonitrile; at 20 ℃; for 0.5h; Schlenk technique; Glovebox;

With triethylsilane; at 20 ℃; for 2h; Schlenk technique; Glovebox;
DOI:10.1002/anie.201905227