2-(5-hydroxy-2-(2-nitro-3-(triisopropylsilyloxy)propyl)phenoxy)-1-(pyrrolidin-1-yl)ethanone

Base Information

Chemical Name:2-(5-hydroxy-2-(2-nitro-3-(triisopropylsilyloxy)propyl)phenoxy)-1-(pyrrolidin-1-yl)ethanone
CAS No.:950487-10-2
Molecular Formula:C₂₄H₄₀N₂O₆Si
Molecular Weight:480.677
Hs Code.:

Synonyms:2-(5-hydroxy-2-(2-nitro-3-(triisopropylsilyloxy)propyl)phenoxy)-1-(pyrrolidin-1-yl)ethanone

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Chemical Property of 2-(5-hydroxy-2-(2-nitro-3-(triisopropylsilyloxy)propyl)phenoxy)-1-(pyrrolidin-1-yl)ethanone

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Technology Process of 2-(5-hydroxy-2-(2-nitro-3-(triisopropylsilyloxy)propyl)phenoxy)-1-(pyrrolidin-1-yl)ethanone

There total 3 articles about 2-(5-hydroxy-2-(2-nitro-3-(triisopropylsilyloxy)propyl)phenoxy)-1-(pyrrolidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 950487-30-6
C₂₉H₄₈N₂O₈Si

: 950487-10-2
2-(5-hydroxy-2-(2-nitro-3-(triisopropylsilyloxy)propyl)phenoxy)-1-(pyrrolidin-1-yl)ethanone

Guidance literature:: With zinc dibromide; In nitromethane; for 1.5h;
DOI:10.1021/ol0710257

Reference yield:

: 950487-13-5
tert-butyl 3-hydroxy-4-(2-nitro-3-(triisopropylsilyloxy)propyl)phenyl carbonate

: 950487-10-2
2-(5-hydroxy-2-(2-nitro-3-(triisopropylsilyloxy)propyl)phenoxy)-1-(pyrrolidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 47 percent / NaH; tetra-n-butylammonium iodide / tetrahydrofuran / 72 h / Heating

2: 86 percent / ZnBr₂ / nitromethane / 1.5 h

With tetra-(n-butyl)ammonium iodide; sodium hydride; zinc dibromide; In tetrahydrofuran; nitromethane;
DOI:10.1021/ol0710257

Reference yield:

: 482580-72-3
3-nitro-O-triisopropylsilyl-1-ethanol

: 950487-10-2
2-(5-hydroxy-2-(2-nitro-3-(triisopropylsilyloxy)propyl)phenoxy)-1-(pyrrolidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: t-BuONa / tetrahydrofuran / 0 °C

1.2: tetrahydrofuran / -78 - 0 °C

1.3: 49 percent / NaBH₄ / tetrahydrofuran; H₂O / 0.42 h

2.1: 47 percent / NaH; tetra-n-butylammonium iodide / tetrahydrofuran / 72 h / Heating

3.1: 86 percent / ZnBr₂ / nitromethane / 1.5 h

With tetra-(n-butyl)ammonium iodide; sodium hydride; zinc dibromide; sodium t-butanolate; In tetrahydrofuran; nitromethane;
DOI:10.1021/ol0710257