N-(2-(4-bromophenyl)-1H-benzo[d]imidazol-5-yl)-3-(4-ethylpiperazin-1-yl)propanamide

Base Information

Chemical Name:N-(2-(4-bromophenyl)-1H-benzo[d]imidazol-5-yl)-3-(4-ethylpiperazin-1-yl)propanamide
CAS No.:1329517-19-2
Molecular Formula:C₂₂H₂₆BrN₅O
Molecular Weight:456.385
Hs Code.:

Synonyms:N-(2-(4-bromophenyl)-1H-benzo[d]imidazol-5-yl)-3-(4-ethylpiperazin-1-yl)propanamide

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Chemical Property of N-(2-(4-bromophenyl)-1H-benzo[d]imidazol-5-yl)-3-(4-ethylpiperazin-1-yl)propanamide

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Technology Process of N-(2-(4-bromophenyl)-1H-benzo[d]imidazol-5-yl)-3-(4-ethylpiperazin-1-yl)propanamide

There total 5 articles about N-(2-(4-bromophenyl)-1H-benzo[d]imidazol-5-yl)-3-(4-ethylpiperazin-1-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 5308-25-8
4-ethylpiperazine

: 1329517-02-3
N-(2-(4-bromophenyl)-1H-benzo[d]imidazol-5-yl)-3-chloropropanamide

: 1329517-19-2
N-(2-(4-bromophenyl)-1H-benzo[d]imidazol-5-yl)-3-(4-ethylpiperazin-1-yl)propanamide

Guidance literature:: With potassium iodide; In tetrahydrofuran; for 3h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2011.06.022

Reference yield:

: 1093760-41-8
2-(4-bromophenyl)-6-nitro-1H-benzimidazole

: 1329517-19-2
N-(2-(4-bromophenyl)-1H-benzo[d]imidazol-5-yl)-3-(4-ethylpiperazin-1-yl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tin(ll) chloride / ethanol / 4 h / Inert atmosphere; Reflux

1.2: Inert atmosphere

2.1: 4 h / Reflux

2.2: pH 8 - 9

3.1: potassium iodide / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

With potassium iodide; tin(ll) chloride; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmc.2011.06.022

Reference yield:

: 351226-76-1
2-(4-bromophenyl)-1H-benzo[d]imidazole-5-amine

: 1329517-19-2
N-(2-(4-bromophenyl)-1H-benzo[d]imidazol-5-yl)-3-(4-ethylpiperazin-1-yl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4 h / Reflux

1.2: pH 8 - 9

2.1: potassium iodide / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

With potassium iodide; In tetrahydrofuran;
DOI:10.1016/j.bmc.2011.06.022