Chemical Property of 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine
Chemical Property:
- Vapor Pressure:4.79E-17mmHg at 25°C
- Refractive Index:1.647
- Boiling Point:655.2 °C at 760 mmHg
- PKA:4.08±0.50(Predicted)
- Flash Point:350.1 °C
- PSA：98.15000
- Density:1.31 g/cm3
- LogP:4.53030
- Storage Temp.:Desiccate at RT
- Solubility.:insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥42.1 mg/mL in EtOH
- XLogP3:2.2
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:5
- Exact Mass:371.14159610
- Heavy Atom Count:26
- Complexity:556
- Purity/Quality:
-
99%, *data from raw suppliers
AZD5438 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1=NC=C(N1C(C)C)C2=NC(=NC=C2)NC3=CC=C(C=C3)S(=O)(=O)C
- Recent ClinicalTrials:AZD5438 in Patients With Advanced Solid Malignancies
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Uses
AZD 5438 is a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, which leads to leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.
