3-(2,4-bis(trifluoromethyl)phenyl)-5-((2-bromo-5H-imidazo[4,5-d]pyridazin-5-yl)methyl)isoxazole

Base Information

Chemical Name:3-(2,4-bis(trifluoromethyl)phenyl)-5-((2-bromo-5H-imidazo[4,5-d]pyridazin-5-yl)methyl)isoxazole
CAS No.:1105059-09-3
Molecular Formula:C₁₇H₈BrF₆N₅O
Molecular Weight:492.178
Hs Code.:

Synonyms:3-(2,4-bis(trifluoromethyl)phenyl)-5-((2-bromo-5H-imidazo[4,5-d]pyridazin-5-yl)methyl)isoxazole

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Chemical Property of 3-(2,4-bis(trifluoromethyl)phenyl)-5-((2-bromo-5H-imidazo[4,5-d]pyridazin-5-yl)methyl)isoxazole

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Technology Process of 3-(2,4-bis(trifluoromethyl)phenyl)-5-((2-bromo-5H-imidazo[4,5-d]pyridazin-5-yl)methyl)isoxazole

There total 5 articles about 3-(2,4-bis(trifluoromethyl)phenyl)-5-((2-bromo-5H-imidazo[4,5-d]pyridazin-5-yl)methyl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 858938-92-8
3-(2,4-(bis-trifluoromethyl)phenyl)-5-(chloromethyl)isoxazole

: 1105059-07-1
2-bromo-5H-imidazo[4,5-d]pyridazine

: 1105059-09-3
3-(2,4-bis(trifluoromethyl)phenyl)-5-((2-bromo-5H-imidazo[4,5-d]pyridazin-5-yl)methyl)isoxazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 1h;

Reference yield: 68.0%

: 858938-92-8
3-(2,4-(bis-trifluoromethyl)phenyl)-5-(chloromethyl)isoxazole

: 1494717-93-9
2-bromo-1H-imidazo[4,5-d]pyridazine

: 1105059-09-3
3-(2,4-bis(trifluoromethyl)phenyl)-5-((2-bromo-5H-imidazo[4,5-d]pyridazin-5-yl)methyl)isoxazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 1h;
DOI:10.1021/jm401337x

Reference yield:

: 59664-42-5
2,4-bis(trifluoromethyl)benzaldehyde

: 1105059-09-3
3-(2,4-bis(trifluoromethyl)phenyl)-5-((2-bromo-5H-imidazo[4,5-d]pyridazin-5-yl)methyl)isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 20 °C

2: sodium hypochlorite / water; dichloromethane / 3.25 h / 0 °C / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 40 °C

With sodium hypochlorite; hydroxylamine hydrochloride; potassium carbonate; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm401337x