4-(2-acrylamidophenylamino)-2-(2-methoxy-4-morpholino phenylamino)-N-methylpyrimidine-5-carboxamide

Base Information

Chemical Name:4-(2-acrylamidophenylamino)-2-(2-methoxy-4-morpholino phenylamino)-N-methylpyrimidine-5-carboxamide
CAS No.:1622001-59-5
Molecular Formula:C₂₆H₂₉N₇O₄
Molecular Weight:503.561
Hs Code.:

Synonyms:4-(2-acrylamidophenylamino)-2-(2-methoxy-4-morpholino phenylamino)-N-methylpyrimidine-5-carboxamide

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Chemical Property of 4-(2-acrylamidophenylamino)-2-(2-methoxy-4-morpholino phenylamino)-N-methylpyrimidine-5-carboxamide

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Technology Process of 4-(2-acrylamidophenylamino)-2-(2-methoxy-4-morpholino phenylamino)-N-methylpyrimidine-5-carboxamide

There total 3 articles about 4-(2-acrylamidophenylamino)-2-(2-methoxy-4-morpholino phenylamino)-N-methylpyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 209960-91-8
2-methoxy-4-morpholinoaniline

: 1622003-30-8
4-(2-acrylamidophenylamino)-2-chloro-N-methylpyrimidine-5-carboxamide

: 1622001-59-5
4-(2-acrylamidophenylamino)-2-(2-methoxy-4-morpholino phenylamino)-N-methylpyrimidine-5-carboxamide

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; at 100 ℃; for 1h;

Reference yield:

: 2972-52-3
2,4-dichloropyrimidine-5-carbonyl chloride

: 1622001-59-5
4-(2-acrylamidophenylamino)-2-(2-methoxy-4-morpholino phenylamino)-N-methylpyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane; tetrahydrofuran / 1 h / -78 °C

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 120 °C

3: toluene-4-sulfonic acid / 1,4-dioxane / 1 h / 100 °C

With toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

: 39714-33-5
2,4-dichloro-N-methylpyrimidine-5-carboxamide

: 1622001-59-5
4-(2-acrylamidophenylamino)-2-(2-methoxy-4-morpholino phenylamino)-N-methylpyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 120 °C

2: toluene-4-sulfonic acid / 1,4-dioxane / 1 h / 100 °C

With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one;