(S)-3-dimethoxymethyl-6-methyl-2-(p-tolylsulfonyl)-2,3-dihydropyridazine-4-carbaldehyde

Base Information

Chemical Name:(S)-3-dimethoxymethyl-6-methyl-2-(p-tolylsulfonyl)-2,3-dihydropyridazine-4-carbaldehyde
CAS No.:1359738-62-7
Molecular Formula:C₁₆H₂₀N₂O₅S
Molecular Weight:352.411
Hs Code.:

Synonyms:(S)-3-dimethoxymethyl-6-methyl-2-(p-tolylsulfonyl)-2,3-dihydropyridazine-4-carbaldehyde

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Chemical Property of (S)-3-dimethoxymethyl-6-methyl-2-(p-tolylsulfonyl)-2,3-dihydropyridazine-4-carbaldehyde

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Technology Process of (S)-3-dimethoxymethyl-6-methyl-2-(p-tolylsulfonyl)-2,3-dihydropyridazine-4-carbaldehyde

There total 2 articles about (S)-3-dimethoxymethyl-6-methyl-2-(p-tolylsulfonyl)-2,3-dihydropyridazine-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1359738-72-9
(E)-4-methyl-N'-(1-oxopropan-2-ylidene)benzenesulfonohydrazide

: 18778-96-6,4093-49-6
4,4-dimethoxy-but-2-enal

: 1359738-62-7
(S)-3-dimethoxymethyl-6-methyl-2-(p-tolylsulfonyl)-2,3-dihydropyridazine-4-carbaldehyde

Guidance literature:: With (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; benzoic acid; In toluene; at 20 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1039/c2cc17370k

Reference yield:

: 1576-35-8
toluene-4-sulfonic acid hydrazide

: 1359738-62-7
(S)-3-dimethoxymethyl-6-methyl-2-(p-tolylsulfonyl)-2,3-dihydropyridazine-4-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: sodium sulfate / diethyl ether; water / 18 h / 20 °C

2: (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; benzoic acid / toluene / 20 °C

With (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; sodium sulfate; benzoic acid; In diethyl ether; water; toluene;
DOI:10.1039/c2cc17370k