(2S,3aS,6aS)-benzyl octahydrocyclopenta[b]pyrrole-2-carboxylate 4-toluenesulfonate (1:1)

Base Information

• Chemical Name: (2S,3aS,6aS)-benzyl octahydrocyclopenta[b]pyrrole-2-carboxylate 4-toluenesulfonate (1:1)
• CAS No.: 852546-84-0
• Molecular Formula: C₇H₈O₃S*C₁₅H₁₉NO₂
• Molecular Weight: 417.526
• Mol file: 852546-84-0.mol

Synonyms:(2S,3aS,6aS)-benzyl octahydrocyclopenta[b]pyrrole-2-carboxylate 4-toluenesulfonate (1:1)

Chemical Property of (2S,3aS,6aS)-benzyl octahydrocyclopenta[b]pyrrole-2-carboxylate 4-toluenesulfonate (1:1)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3aS,6aS)-benzyl octahydrocyclopenta[b]pyrrole-2-carboxylate 4-toluenesulfonate (1:1)

There total 3 articles about (2S,3aS,6aS)-benzyl octahydrocyclopenta[b]pyrrole-2-carboxylate 4-toluenesulfonate (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2S,3aS,6aS)-1-(tert-butoxycarbonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid (109428-53-7,411232-21-8,726691-28-7) + toluene-4-sulfonic acid (104-15-4) + benzyl alcohol (100-51-6,185532-71-2) → (2S,3aS,6aS)-benzyl octahydrocyclopenta[b]pyrrole-2-carboxylate 4-toluenesulfonate (1:1) (852546-84-0)

Guidance literature:

In toluene; for 8h; Heating;

Reference yield: 90.0%

(2S)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid (411232-21-8,726691-28-7) + toluene-4-sulfonic acid (104-15-4) + benzyl alcohol (100-51-6,185532-71-2) → (2S,3aS,6aS)-benzyl octahydrocyclopenta[b]pyrrole-2-carboxylate 4-toluenesulfonate (1:1) (852546-84-0)

Guidance literature:

In toluene; for 8h; Heating / reflux;

Reference yield:

phenylmethyl-2-azabicyclo[3.3.0]-octane-3-carboxylate tosylate + toluene-4-sulfonic acid (104-15-4) → (2S,3aS,6aS)-benzyl octahydrocyclopenta[b]pyrrole-2-carboxylate 4-toluenesulfonate (1:1) (852546-84-0)

Guidance literature:

phenylmethyl-2-azabicyclo[3.3.0]-octane-3-carboxylate tosylate; With sodium hydroxide; In water; for 0.5h; pH=9 - 10; Resolution of racemate;

toluene-4-sulfonic acid; In dichloromethane; at 25 ℃; for 0.25h; Purification / work up; Resolution of racemate;

upstream raw materials:

(2S)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid

toluene-4-sulfonic acid

benzyl alcohol

(2S,3aS,6aS)-1-(tert-butoxycarbonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid

Downstream raw materials:

2--L-alanyl>-(1S,3S,5S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid benzylester

Refernces

• 1、 -. "NOVEL CARBAMOYLGLYCINE DERIVATIVES". Page/Page column 14. . Retrieved 2009/05/28.
• 2、 -. "NOVEL 5-SUBSTITUTED HYDANTOINS". Page/Page column 18. . Retrieved 2009/01/24.