(1S)-2-Amino-1-(4-methylphenyl)ethan-1-ol

Base Information

Chemical Name:(1S)-2-Amino-1-(4-methylphenyl)ethan-1-ol
CAS No.:149403-05-4
Molecular Formula:C9H13 N O
Molecular Weight:151.21
Hs Code.:
DSSTox Substance ID:DTXSID70498117
Nikkaji Number:J1.719.302C
Wikidata:Q82347974
Mol file:149403-05-4.mol

Synonyms:149403-05-4;(1S)-2-Amino-1-(4-methylphenyl)ethan-1-ol;(1S)-2-AMINO-1-(4-METHYLPHENYL)ETHANOL;BENZENEMETHANOL, A-(AMINOMETHYL)-4-METHYL-, (S)-;(S)-(Aminomethyl)-4-methyl-benzenemethanol;SCHEMBL6675367;DTXSID70498117;AKOS017516186;(S)-2-amino-1-(p-tolyl)ethan-1-ol;CS-0003882;EN300-182522

Suppliers and Price of (1S)-2-Amino-1-(4-methylphenyl)ethan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(S)-ALPHA-(AMINOMETHYL)-4-METHYL-BENZENEMETHANOL 95.00%
5MG
$ 495.88

Total 10 raw suppliers

Chemical Property of (1S)-2-Amino-1-(4-methylphenyl)ethan-1-ol

Chemical Property:

Vapor Pressure:0.000484mmHg at 25°C
Boiling Point:300.9°C at 760 mmHg
Flash Point:135.8°C
PSA：46.25000
Density:1.076g/cm³
LogP:1.68740
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:151.099714038
Heavy Atom Count:11
Complexity:108

Purity/Quality:

99% ^*data from raw suppliers

(S)-ALPHA-(AMINOMETHYL)-4-METHYL-BENZENEMETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C(CN)O
Isomeric SMILES:CC1=CC=C(C=C1)[C@@H](CN)O

Technology Process of (1S)-2-Amino-1-(4-methylphenyl)ethan-1-ol

There total 16 articles about (1S)-2-Amino-1-(4-methylphenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 297765-46-9
(S)-2-azido-1-(4-methylphenyl)ethanol

: 149403-05-4
(S)-1-(4'-methylphenyl)-2-aminoethanol

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 15h;
DOI:10.1016/S0957-4166(02)00322-1

Reference yield:

: 5467-70-9
2-amino-4'-methylacetophenone hydrochloride

: 149403-05-4
(S)-1-(4'-methylphenyl)-2-aminoethanol

: 97642-98-3
(R)-1-(4'-methylphenyl)-2-aminoethanol

Guidance literature:: With hydrogen; potassium carbonate; [Rh(R,R,S,S-DuanPhos)(nbd)]SbF₆; In 2,2,2-trifluoroethanol; at 20 ℃; for 12h; under 7600.51 Torr; Title compound not separated from byproducts.;
DOI:10.1002/chem.200700594

Reference yield:

: 62968-73-4
2-nitro-1-(p-tolyl)ethan-1-one

: 149403-05-4
(S)-1-(4'-methylphenyl)-2-aminoethanol

Guidance literature:: Multi-step reaction with 2 steps

1: RuCl[(S,S)-N-(p-Ts)-1,2-diphenylethylenediamine](p-cymene); HCO₂H; Et₃N / dimethylformamide / 16 h / 30 °C

2: H₂ / Pd/C / methanol

With formic acid; RuCl(p-cymene)[N-(p-tosyl)-(1R,2R)-diphenylethylenediamine]; hydrogen; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo011076w