5-{2-[2-(4-Benzoylamino-piperidin-1-yl)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide

Base Information

Chemical Name:5-{2-[2-(4-Benzoylamino-piperidin-1-yl)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide
CAS No.:81579-57-9
Molecular Formula:C₂₄H₃₂N₄O₄
Molecular Weight:440.542
Hs Code.:

Synonyms:5-{2-[2-(4-Benzoylamino-piperidin-1-yl)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide

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Chemical Property of 5-{2-[2-(4-Benzoylamino-piperidin-1-yl)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide

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Technology Process of 5-{2-[2-(4-Benzoylamino-piperidin-1-yl)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide

There total 4 articles about 5-{2-[2-(4-Benzoylamino-piperidin-1-yl)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 81579-48-8
5-{2-[2-(4-Benzoylamino-piperidin-1-yl)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzoic acid methyl ester

: 81579-57-9
5-{2-[2-(4-Benzoylamino-piperidin-1-yl)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide

Guidance literature:: With ammonium hydroxide; for 192h; Ambient temperature;
DOI:10.1021/jm00348a013

Reference yield:

: 36270-04-9
methyl-5-(N,N-dibenzylglycyl) salicylate

: 81579-57-9
5-{2-[2-(4-Benzoylamino-piperidin-1-yl)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / H₂, AcOH / 10percent PdO/C, 10percent Pt/C / methanol / 760 Torr / Ambient temperature

2: 86 percent / NH₄OH / 192 h / Ambient temperature

With ammonium hydroxide; hydrogen; acetic acid; platinum on activated charcoal; palladium oxide on charcoal; In methanol;
DOI:10.1021/jm00348a013

Reference yield:

: 33953-37-6
N-(piperidin-4-yl)benzamide

: 81579-57-9
5-{2-[2-(4-Benzoylamino-piperidin-1-yl)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / NaHCO₃ / ethanol / 21 h

2: 51 percent / H₂, AcOH / 10percent PdO/C, 10percent Pt/C / methanol / 760 Torr / Ambient temperature

3: 86 percent / NH₄OH / 192 h / Ambient temperature

With ammonium hydroxide; hydrogen; sodium hydrogencarbonate; acetic acid; platinum on activated charcoal; palladium oxide on charcoal; In methanol; ethanol;
DOI:10.1021/jm00348a013