3-(2-tert-butoxycarbonylamino-1-hydroxy-ethyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid benzyl ester

Base Information

Chemical Name:3-(2-tert-butoxycarbonylamino-1-hydroxy-ethyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid benzyl ester
CAS No.:1025982-39-1
Molecular Formula:C₃₈H₃₈N₂O₆
Molecular Weight:618.73
Hs Code.:

3-(2-<i>tert</i>-butoxycarbonylamino-1-hydroxy-ethyl)-4-oxo-1-(9-phenyl-9<i>H</i>-fluoren-9-yl)-pyrrolidine-2-carboxylic acid benzyl ester

Synonyms:3-(2-tert-butoxycarbonylamino-1-hydroxy-ethyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid benzyl ester

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Chemical Property of 3-(2-tert-butoxycarbonylamino-1-hydroxy-ethyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid benzyl ester

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Technology Process of 3-(2-tert-butoxycarbonylamino-1-hydroxy-ethyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid benzyl ester

There total 1 articles about 3-(2-tert-butoxycarbonylamino-1-hydroxy-ethyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89711-08-0
N-(t-butoxycarbonyl)glycinal

: 163594-14-7
(2S)-4-oxo-N-(9-phenylfluoren-9-yl)proline benzyl ester

: 1025982-39-1
3-(2-tert-butoxycarbonylamino-1-hydroxy-ethyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: (2S)-4-oxo-N-(9-phenylfluoren-9-yl)proline benzyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -55 ℃; for 1h;

N-(t-butoxycarbonyl)glycinal; In tetrahydrofuran; hexane; at -55 ℃; for 5h;
DOI:10.1021/jo049612i

Reference yield:

: 1025982-39-1
3-(2-tert-butoxycarbonylamino-1-hydroxy-ethyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid benzyl ester

: 5-(9-phenyl-9H-fluoren-9-yl)-1,4,5,6-tetrahydro-pyrrolo[3,4-b]pyrrole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.11 g / HCl / CH₂Cl₂ / 12 h

2: 79 percent / 0.58 h / 180 °C

3: H₂ / Pd(OH)2/C / tetrahydrofuran; methanol / 5320 Torr

With hydrogenchloride; hydrogen; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo049612i

Reference yield:

: 1025982-39-1
3-(2-tert-butoxycarbonylamino-1-hydroxy-ethyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid benzyl ester

: 4-(1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-4,6-dihydro-1H-pyrrolo[3,4-b]pyrrole-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.11 g / HCl / CH₂Cl₂ / 12 h

2: 79 percent / 0.58 h / 180 °C

3: 40 percent / H₂ / Pd(OH)2/C / tetrahydrofuran; methanol / 24 h / 760 Torr

4: TBTU; Et₃N / acetonitrile / 12 h / 20 °C

With hydrogenchloride; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo049612i