2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxyuridine

Base Information

Chemical Name:2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxyuridine
CAS No.:219618-94-7
Molecular Formula:C₄₇H₆₃N₃O₆Si₃
Molecular Weight:850.29
Hs Code.:

2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'-<N-(tert-butyldiphenylsilyl)oxyamino>-3'-deoxyuridine

Synonyms:2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxyuridine

Suppliers and Price of 2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxyuridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxyuridine

Chemical Property:

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Technology Process of 2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxyuridine

There total 4 articles about 2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 218967-53-4
2'-O-(tert-butyldimethylsilyl)-3'-deoxy-3-(hydroxylamino)uridine

: 219618-94-7
2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxyuridine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 24h; Ambient temperature;
DOI:10.1021/jm980466g

Reference yield:

: 90813-54-0
2',5'-bis-O-tert-butyldimethylsilyl-3'-ketouridine

: 219618-94-7
2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxyuridine

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / NH₂OH*HCl, pyridine / 0.33 h / Ambient temperature

2: 99 percent / 80 percent aq. TFA / 0.5 h / 0 °C

3: 92 percent / NaBH₄, AcOH / 2 h / 0 °C

4: 90 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

With pyridine; 1H-imidazole; sodium tetrahydroborate; hydroxylamine hydrochloride; acetic acid; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm980466g

Reference yield:

: 218967-30-7
1-<2-O-(tert-butyldimethylsilyl)-3-deoxy-3-(hydroxyimino)-β-D-erythro-pentofuranosyl>uracil

: 219618-94-7
2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / NaBH₄, AcOH / 2 h / 0 °C

2: 90 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm980466g