1H-Pyrrolizine-7a(5H)-carboxylicacid,tetrahydro-3-oxo-(9CI)

Base Information

• Chemical Name: 1H-Pyrrolizine-7a(5H)-carboxylicacid,tetrahydro-3-oxo-(9CI)
• CAS No.: 216392-66-4
• Molecular Formula: C₈H₁₁NO₃
• Molecular Weight: 169.18
• Hs Code.: 2933990090
• Mol file: 216392-66-4.mol

Synonyms:1H-Pyrrolizine-7a(5H)-carboxylicacid,tetrahydro-3-oxo-(9CI);1H-Pyrrolizine-7a(5H)-carboxylic acid, tetrahydro-3-oxo-;1-Oxotetrahydro-1H-pyrrolizine-7a(5H)-carboxylic acid hydrochloride

Chemical Property of 1H-Pyrrolizine-7a(5H)-carboxylicacid,tetrahydro-3-oxo-(9CI)

Chemical Property:

• Vapor Pressure: 2.1E-06mmHg at 25°C
• Boiling Point: 367.4°Cat760mmHg
• PKA: 3.67±0.20(Predicted)
• Flash Point: 176°C
• PSA: 57.61000
• Density: g/cm³
• LogP: 0.16390

Purity/Quality:

97% ^*data from raw suppliers

Tetrahydro-3-oxo-1H-pyrrolizine-7a(5H)-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolizine-7a(5H)-carboxylicacid,tetrahydro-3-oxo-(9CI)

There total 7 articles about 1H-Pyrrolizine-7a(5H)-carboxylicacid,tetrahydro-3-oxo-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-Oxo-tetrahydro-pyrrolizine-7a-carboxylic acid benzyl ester (216392-65-3) → (R)-3-Oxo-tetrahydro-pyrrolizine-7a-carboxylic acid (216392-66-4)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1021/ja9815071

Reference yield:

N-carbobenzyloxy-L-proline methyl ester (5211-23-4) → (R)-3-Oxo-tetrahydro-pyrrolizine-7a-carboxylic acid (216392-66-4)

Guidance literature:

Multi-step reaction with 7 steps

1: lithium bis(trimethylsilyl)amide

2: 1.) disiamylborane, 2.) H₂O₂, NaOH

3: Jones reagent

4: H₂ / Pd/C

5: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

6: Ti(O-iPr)4

7: H₂ / Pd/C

With titanium(IV) isopropylate; sodium hydroxide; jones reagent; hydrogen; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; palladium on activated charcoal;

DOI:10.1021/ja9815071

Reference yield:

(R)-N-(benzoyloxycarbonyl)-allylproline methyl ester (157662-40-3) → (R)-3-Oxo-tetrahydro-pyrrolizine-7a-carboxylic acid (216392-66-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) disiamylborane, 2.) H₂O₂, NaOH

2: Jones reagent

3: H₂ / Pd/C

4: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

5: Ti(O-iPr)4

6: H₂ / Pd/C

With titanium(IV) isopropylate; sodium hydroxide; jones reagent; hydrogen; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal;

DOI:10.1021/ja9815071

upstream raw materials:

(R)-3-Oxo-tetrahydro-pyrrolizine-7a-carboxylic acid benzyl ester

N-carbobenzyloxy-L-proline methyl ester

(R)-N-(benzoyloxycarbonyl)-allylproline methyl ester

(R)-2-(3-Hydroxy-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

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