(1R,3aR,4R,7aR)-6-Benzenesulfonyl-1-((R)-1-benzenesulfonylmethyl-pent-4-enyl)-7a-methyl-octahydro-inden-4-ol

Base Information

Chemical Name:(1R,3aR,4R,7aR)-6-Benzenesulfonyl-1-((R)-1-benzenesulfonylmethyl-pent-4-enyl)-7a-methyl-octahydro-inden-4-ol
CAS No.:132713-32-7
Molecular Formula:C₂₈H₃₆O₅S₂
Molecular Weight:516.723
Hs Code.:

Synonyms:(1R,3aR,4R,7aR)-6-Benzenesulfonyl-1-((R)-1-benzenesulfonylmethyl-pent-4-enyl)-7a-methyl-octahydro-inden-4-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3aR,4R,7aR)-6-Benzenesulfonyl-1-((R)-1-benzenesulfonylmethyl-pent-4-enyl)-7a-methyl-octahydro-inden-4-ol

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Technology Process of (1R,3aR,4R,7aR)-6-Benzenesulfonyl-1-((R)-1-benzenesulfonylmethyl-pent-4-enyl)-7a-methyl-octahydro-inden-4-ol

There total 1 articles about (1R,3aR,4R,7aR)-6-Benzenesulfonyl-1-((R)-1-benzenesulfonylmethyl-pent-4-enyl)-7a-methyl-octahydro-inden-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 132713-31-6
(S)-2-[(1R,2R,3R)-2-(2-Benzenesulfonyl-ethyl)-3-((R)-1-benzenesulfonylmethyl-pent-4-enyl)-2-methyl-cyclopentyl]-oxirane

: 132713-32-7
(1R,3aR,4R,7aR)-6-Benzenesulfonyl-1-((R)-1-benzenesulfonylmethyl-pent-4-enyl)-7a-methyl-octahydro-inden-4-ol

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; -78 deg C, 30 min, then 0 deg C, 1h;
DOI:10.1016/S0040-4039(00)97025-4

Reference yield:

: 132713-32-7
(1R,3aR,4R,7aR)-6-Benzenesulfonyl-1-((R)-1-benzenesulfonylmethyl-pent-4-enyl)-7a-methyl-octahydro-inden-4-ol

: 70550-73-1
(1R,3aR,7aR)-1-[(2R)-6-hydroxy-6-methylhept-2-yl]-7a-methyloctahydroinden-4-one

Guidance literature:: Multi-step reaction with 8 steps

1: 49 percent / Na-Hg, Na₂HPO₄ / methanol / 1 h / 25 °C

2: 95 percent / DMAP, Et₃N / CH₂Cl₂ / 5 h / 25 °C

3: 1.) BH₃Me₂S, 2.) 30percent H₂O₂, 10percent NaOH / 1.) THF, 0 deg C, 30 min, 2.) MeOH, 0 deg C, 30 min

4: PDC / dimethylformamide / 20 h / 25 °C

5: diethyl ether / 0.17 h

6: 93 percent / tetrahydrofuran / 1 h / 25 °C

7: nBu₄NF / tetrahydrofuran / 20 h / 25 °C

8: PCC, molecular sieves (4 Angstroem) / CH₂Cl₂ / 1 h / 25 °C

With dmap; sodium hydroxide; disodium hydrogenphosphate; dipyridinium dichromate; sodium amalgam; dimethylsulfide borane complex; 4 A molecular sieve; tetrabutyl ammonium fluoride; dihydrogen peroxide; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)97025-4