3-(4-fluorophenyl)-1-(5-hydroxy-2,2,8,8-tetramethyl-2H,8H-pyrano[2,3-f]chromen-6-yl)-propenone

Base Information

• Chemical Name: 3-(4-fluorophenyl)-1-(5-hydroxy-2,2,8,8-tetramethyl-2H,8H-pyrano[2,3-f]chromen-6-yl)-propenone
• CAS No.: 1669423-79-3
• Molecular Formula: C₂₅H₂₃FO₄
• Molecular Weight: 406.454

Synonyms:3-(4-fluorophenyl)-1-(5-hydroxy-2,2,8,8-tetramethyl-2H,8H-pyrano[2,3-f]chromen-6-yl)-propenone

Chemical Property of 3-(4-fluorophenyl)-1-(5-hydroxy-2,2,8,8-tetramethyl-2H,8H-pyrano[2,3-f]chromen-6-yl)-propenone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

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Technology Process of 3-(4-fluorophenyl)-1-(5-hydroxy-2,2,8,8-tetramethyl-2H,8H-pyrano[2,3-f]chromen-6-yl)-propenone

There total 3 articles about 3-(4-fluorophenyl)-1-(5-hydroxy-2,2,8,8-tetramethyl-2H,8H-pyrano[2,3-f]chromen-6-yl)-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(5-hydroxy-2,2,8,8-tetramethyl-2,8-dihydropyrano[2,3-f]chromen-6-yl)ethanone (31380-12-8) + 4-fluorobenzaldehyde (459-57-4) → 3-(4-fluorophenyl)-1-(5-hydroxy-2,2,8,8-tetramethyl-2H,8H-pyrano[2,3-f]chromen-6-yl)-propenone (1669423-79-3)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 20 ℃;

DOI:10.1002/mrc.4062

Reference yield:

2,4,6-trihydroxyacetophenone (480-66-0,67471-34-5) → 3-(4-fluorophenyl)-1-(5-hydroxy-2,2,8,8-tetramethyl-2H,8H-pyrano[2,3-f]chromen-6-yl)-propenone (1669423-79-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 110 °C

2: potassium hydroxide / ethanol; water / 20 °C

With pyridine; potassium hydroxide; In ethanol; water; 2: |Claisen-Schmidt Condensation;

DOI:10.1002/mrc.4062

Reference yield:

3,3-dimethyl acrylaldehyde (107-86-8) → 3-(4-fluorophenyl)-1-(5-hydroxy-2,2,8,8-tetramethyl-2H,8H-pyrano[2,3-f]chromen-6-yl)-propenone (1669423-79-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 110 °C

2: potassium hydroxide / ethanol; water / 20 °C

With pyridine; potassium hydroxide; In ethanol; water; 2: |Claisen-Schmidt Condensation;

DOI:10.1002/mrc.4062

upstream raw materials:

2,4,6-trihydroxyacetophenone

3,3-dimethyl acrylaldehyde

1-(5-hydroxy-2,2,8,8-tetramethyl-2,8-dihydropyrano[2,3-f]chromen-6-yl)ethanone

4-fluorobenzaldehyde

Downstream raw materials:

2-(4-fluorophenyl)-6,6,10,10-tetramethyl-2,3-dihydro-6H,10H-dipyrano[2,3-f;2′,3′-h]chromen-4-one

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