(2R,3R,4S)-N-benzyl-4-(2-oxo-2-phenylethyl)-2-phenyl-1,2,3,4-tetrahydroquinoline-3-carboxamide

Base Information

Chemical Name:(2R,3R,4S)-N-benzyl-4-(2-oxo-2-phenylethyl)-2-phenyl-1,2,3,4-tetrahydroquinoline-3-carboxamide
CAS No.:1454837-46-7
Molecular Formula:C₃₁H₂₈N₂O₂
Molecular Weight:460.576
Hs Code.:

Synonyms:(2R,3R,4S)-N-benzyl-4-(2-oxo-2-phenylethyl)-2-phenyl-1,2,3,4-tetrahydroquinoline-3-carboxamide

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Chemical Property of (2R,3R,4S)-N-benzyl-4-(2-oxo-2-phenylethyl)-2-phenyl-1,2,3,4-tetrahydroquinoline-3-carboxamide

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Technology Process of (2R,3R,4S)-N-benzyl-4-(2-oxo-2-phenylethyl)-2-phenyl-1,2,3,4-tetrahydroquinoline-3-carboxamide

There total 3 articles about (2R,3R,4S)-N-benzyl-4-(2-oxo-2-phenylethyl)-2-phenyl-1,2,3,4-tetrahydroquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1454837-30-9
(4aR,5R,10bS)-2,5-diphenyl-4a,5,6,10b-tetrahydro-4H-pyrano[3,4-c]quinolin-4-one

: 100-46-9
benzylamine

: 1454837-46-7
(2R,3R,4S)-N-benzyl-4-(2-oxo-2-phenylethyl)-2-phenyl-1,2,3,4-tetrahydroquinoline-3-carboxamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 8h; Schlenk technique; Inert atmosphere;
DOI:10.1021/ol4024985

Reference yield:

: 5443-49-2
α-bromocinnamaldehyde

: 108714-18-7
3-(2-aminophenyl)-1-phenylprop-2-en-1-one

: 1454837-46-7
(2R,3R,4S)-N-benzyl-4-(2-oxo-2-phenylethyl)-2-phenyl-1,2,3,4-tetrahydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane; (5aS,10bR)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 8 h / 20 °C / Schlenk technique; Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; (5aS,10bR)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol4024985

Reference yield:

: 108714-18-7
3-(2-aminophenyl)-1-phenylprop-2-en-1-one

: 18365-42-9
α-chloro-cinnamaldehyde

: 1454837-46-7
(2R,3R,4S)-N-benzyl-4-(2-oxo-2-phenylethyl)-2-phenyl-1,2,3,4-tetrahydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane; (5aS,10bR)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 8 h / 20 °C / Schlenk technique; Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; (5aS,10bR)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol4024985