Technology Process of 2-bromomethyl-4-methoxybenzoic acid
There total 6 articles about 2-bromomethyl-4-methoxybenzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 4-methoxy-2-methylbenzoate;
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile);
In
α,α,α-trifluorotoluene;
at 80 ℃;
for 16h;
With
water; sodium hydroxide;
In
α,α,α-trifluorotoluene;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid; nitrogen dioxide / 10 h / 25 °C
2.1: N-hydroxyphthalimide; nitric acid; cobalt(II) chloride; manganese(II) acetate / 10 h / Reflux
3.1: sodium hydroxide / water / 0.17 h
3.2: Raney nickel / 2 h / 90 °C
4.1: sodium nitrite; sulfuric acid / water / 3 h / 0 - 50 °C
5.1: sodium hydroxide / 3 h / 40 - 90 °C / pH 10
6.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / 80 °C
With
N-Bromosuccinimide; N-hydroxyphthalimide; nitrogen dioxide; sulfuric acid; nitric acid; manganese(II) acetate; cobalt(II) chloride; sodium hydroxide; sodium nitrite; dibenzoyl peroxide;
In
tetrachloromethane; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-hydroxyphthalimide; nitric acid; cobalt(II) chloride; manganese(II) acetate / 10 h / Reflux
2.1: sodium hydroxide / water / 0.17 h
2.2: Raney nickel / 2 h / 90 °C
3.1: sodium nitrite; sulfuric acid / water / 3 h / 0 - 50 °C
4.1: sodium hydroxide / 3 h / 40 - 90 °C / pH 10
5.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / 80 °C
With
N-Bromosuccinimide; N-hydroxyphthalimide; sulfuric acid; nitric acid; manganese(II) acetate; cobalt(II) chloride; sodium hydroxide; sodium nitrite; dibenzoyl peroxide;
In
tetrachloromethane; water;
