(5Z,8RS)-8-hydroxymethyl-9-(2-hydroxyphenyl)non-5-enoic acid

Base Information

• Chemical Name: (5Z,8RS)-8-hydroxymethyl-9-(2-hydroxyphenyl)non-5-enoic acid
• CAS No.: 129372-16-3
• Molecular Formula: C₁₆H₂₂O₄
• Molecular Weight: 278.348
• Mol file: 129372-16-3.mol

Synonyms:(5Z,8RS)-8-hydroxymethyl-9-(2-hydroxyphenyl)non-5-enoic acid

Chemical Property of (5Z,8RS)-8-hydroxymethyl-9-(2-hydroxyphenyl)non-5-enoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (5Z,8RS)-8-hydroxymethyl-9-(2-hydroxyphenyl)non-5-enoic acid

There total 2 articles about (5Z,8RS)-8-hydroxymethyl-9-(2-hydroxyphenyl)non-5-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

(5Z)-7-(<2RS,4RS,5SR>-4-o-hydroxyphenyl-2-trifluoromethyl-1,3-dioxan-5-yl)hept-5-enoic acid (102967-52-2,102967-55-5,106393-80-0,141991-70-0) → (5Z,8RS)-8-hydroxymethyl-9-(2-hydroxyphenyl)non-5-enoic acid (129372-16-3) + (5Z,8RS,9SR)-9-hydroxy-8-hydroxymethyl-9-(2-hydroxyphenyl)non-5-enoic acic

Guidance literature:

With water; at 91 ℃; at pH: 10.8;

DOI:10.1039/P29900000965

Reference yield:

(5Z)-7-(<2RS,4RS,5SR>-4-o-hydroxyphenyl-2-trifluoromethyl-1,3-dioxan-5-yl)hept-5-enoic acid (102967-52-2,102967-55-5,106393-80-0,141991-70-0) → 2,2,2-Trifluoroacetaldehyde (75-90-1) + (5Z,8RS)-8-hydroxymethyl-9-(2-hydroxyphenyl)non-5-enoic acid (129372-16-3) + (5Z,8RS,9SR)-9-hydroxy-8-hydroxymethyl-9-(2-hydroxyphenyl)non-5-enoic acic + trifluoroacetic acid (76-05-1)

Guidance literature:

With water; at 91 ℃; Mechanism; Thermodynamic data; Kinetics; acetate, phosphate, carbonate, or borate buffers; other reaction temperatures, different pH's; ΔG(excit.), ΔH(excit.), ΔS(excit.);

DOI:10.1039/P29900000965

upstream raw materials:

(5Z)-7-(<2RS,4RS,5SR>-4-o-hydroxyphenyl-2-trifluoromethyl-1,3-dioxan-5-yl)hept-5-enoic acid