(3S,4S)-4-(1,1-Dimethyl-2-phenyl-ethyl)-3-methyl-2,2,2-triphenyl-2λ⁵-[1,2]oxaphosphetane

Base Information

• Chemical Name: (3S,4S)-4-(1,1-Dimethyl-2-phenyl-ethyl)-3-methyl-2,2,2-triphenyl-2λ⁵-[1,2]oxaphosphetane
• CAS No.: 113773-48-1
• Molecular Formula: C₃₁H₃₃OP
• Molecular Weight: 452.576

Synonyms:(3S,4S)-4-(1,1-Dimethyl-2-phenyl-ethyl)-3-methyl-2,2,2-triphenyl-2λ⁵-[1,2]oxaphosphetane

Chemical Property of (3S,4S)-4-(1,1-Dimethyl-2-phenyl-ethyl)-3-methyl-2,2,2-triphenyl-2λ⁵-[1,2]oxaphosphetane

Chemical Property:

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Technology Process of (3S,4S)-4-(1,1-Dimethyl-2-phenyl-ethyl)-3-methyl-2,2,2-triphenyl-2λ⁵-[1,2]oxaphosphetane

There total 3 articles about (3S,4S)-4-(1,1-Dimethyl-2-phenyl-ethyl)-3-methyl-2,2,2-triphenyl-2λ⁵-[1,2]oxaphosphetane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

((1S,2S)-2-Hydroxy-1,3,3-trimethyl-4-phenyl-butyl)-triphenyl-phosphonium; iodide (113686-99-0) → (3S,4S)-4-(1,1-Dimethyl-2-phenyl-ethyl)-3-methyl-2,2,2-triphenyl-2λ5-[1,2]oxaphosphetane (113773-48-1)

Guidance literature:

With sodium hexamethyldisilazane; In ⁽²⁾H₈-toluene; at -3 ℃; for 0.533333h;

DOI:10.1021/ja00220a036

Reference yield:

2,2-dimethyl-3-phenylpropionaldehyde (1009-62-7) → (3S,4S)-4-(1,1-Dimethyl-2-phenyl-ethyl)-3-methyl-2,2,2-triphenyl-2λ5-[1,2]oxaphosphetane (113773-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, -40 deg C, 30 min; 2.) THF, roomtemp., 30 min

2: 25 percent / NaHMDS / toluene-d8 / 0.53 h / -3 °C

With n-butyllithium; sodium hexamethyldisilazane; In ⁽²⁾H₈-toluene;

DOI:10.1021/ja00220a036

Reference yield:

ethyltriphenylphosphonium iodide (4736-60-1) → (3S,4S)-4-(1,1-Dimethyl-2-phenyl-ethyl)-3-methyl-2,2,2-triphenyl-2λ5-[1,2]oxaphosphetane (113773-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, -40 deg C, 30 min; 2.) THF, roomtemp., 30 min

2: 25 percent / NaHMDS / toluene-d8 / 0.53 h / -3 °C

With n-butyllithium; sodium hexamethyldisilazane; In ⁽²⁾H₈-toluene;

DOI:10.1021/ja00220a036

upstream raw materials:

((1S,2S)-2-Hydroxy-1,3,3-trimethyl-4-phenyl-butyl)-triphenyl-phosphonium; iodide

2,2-dimethyl-3-phenylpropionaldehyde

ethyltriphenylphosphonium iodide

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